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Figure 5 | BMC Infectious Diseases

Figure 5

From: A peptide fragment from the human COX3 protein disrupts association of Mycobacterium tuberculosisvirulence proteins ESAT-6 and CFP10, inhibits mycobacterial growth and mounts protective immune response

Figure 5

HCL2 peptide expressed in M. tuberculosis H37Rv enhances expression of helper T-cells and prime APCs. (A) The percentage of splenic T lymphocytes in H37Rv/HCL2, ΔRD1 and H37Rv infected mice expressing CD4 and CD8 is shown in the bar diagram with mean ± STDEV and Student’s T-test (*p < 0.05). (B) Increased number of Professional APCs was observed in H37Rv/HCL2 infected mice as compared to H37Rv and ΔRD1 infected mice at day 10 after infection. The percentage of cells expressing CD11B and CD11C is shown in the bar diagram with mean ± STDEV and Student’s T-test (*p < 0.05). (C) Total cytokine production by splenocytes is shown by bar diagram. Data shown with mean ± STDEV and Student’s T-test was applied for estimating significance between two parameters (*P < 0.05).

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BMC Infectious Diseases

ISSN: 1471-2334

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