Table 5 Predictors of treatment interruption (compared to cures) (n = 457) †
Variable | Univariate | Multivariate‡ | |||
|---|---|---|---|---|---|
OR | 95% CI | OR | 95% CI | ||
Gender | Female | 1 | 1 | ||
Male | 1.48 | 0.79-2.78 | 1.53 | 0.78-3.00 | |
Age | 20-34 | 1 | 1 | ||
35-49 | 1.16 | 0.69-1.95 | 0.92 | 0.53-1.59 | |
≥50 | 0.67 | 0.38-1.18 | 0.63 | 0.34-1.16 | |
Body Mass Index (n = 446) | <18.5 | 1 | - | ||
≥18.5 | 0.78 | 0.51-1.91 | |||
Diabetes | No | 1 | - | ||
Yes | 1.56 | 0.95-2.56 | |||
Alcohol, within 6 months | Less than once a week | 1 | - | ||
Several times a week | 1.71 | 0.96-3.05 | |||
At least once a day | 2.03** | 1.27-3.24 | |||
Smoking, within 6 months | Never smoked | 1 | - | ||
< 1 pack/day | 2.68** | 1.31-5.49 | |||
1 pack/day | 3.36*** | 1.75-6.46 | |||
> 1 pack/day | 3.12** | 1.54-6.32 | |||
Residence | Small city and town | 1 | - | ||
Large city | 1.20 | 0.79-1.83 | |||
Education | High school, above | 1 | - | ||
Middle school, below or refusal | 1.20 | 0.80-1.82 | |||
Occupation | Unemployment and others | 1 | 1 | ||
Health care, professional and office work | 1.14 | 0.47-2.75 | 0.89 | 0.35-2.25 | |
Service sector and laborer | 2.39** | 1.45-3.95 | 2.30** | 1.36-3.90 | |
Chest X-ray | |||||
Grade | Minimal or moderate | 1 | - | ||
Far advanced | 1.34 | 0.89-2.04 | |||
Cavity | No | 1 | - | ||
Yes or not clear | 1.04 | 0.63-1.69 | |||
Nodular lesion | No | 1 | - | ||
Yes or not clear | 2.07 | 0.70-6.14 | |||
Bilateral | Unilateral | 1 | 1 | ||
Bilateral | 2.86** | 1.46-5.60 | 2.46* | 1.22-4.95 | |
Number of previous treatment episode | 0 (new case) | 1 | - | ||
1 | 1.54 | 0.87-2.71 | |||
2 | 2.77** | 1.53-5.02 | |||
≥3 | 2.40** | 1.35-4.27 | |||
History of failure | No | 1 | 1 | ||
Yes | 1.81* | 1.12-2.92 | 1.76* | 1.04-2.98 | |
History of TI | No | 1 | 1 | ||
Yes | 2.72*** | 1.77-4.18 | 2.35*** | 1.49-3.70 | |
Elevation of total bilirubin | No | 1 | |||
Yes | 0.63* | 0.40-1.00 | |||
Elevation of liver enzyme | No | 1 | |||
Yes | 0.95 | 0.55-1.65 | |||
Number of significant regimen changes | 0 | 1 | - | ||
≥1 | 1.62* | 1.04-2.55 | |||
Drug susceptibility pattern (n = 403) | DS | 1 | - | ||
Mono/poly-R | 1.25 | 0.66-2.39 | |||
Rif, mono-R | 2.01 | 0.68-5.92 | |||
MDR | 1.45 | 0.88-2.39 | |||