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Table 6 Sensitivity analysis exploring the influence of the degree of Influenza B lineage cross protection L

From: 4Flu - an individual based simulation tool to study the effects of quadrivalent vaccination on seasonal influenza in Germany

L

Influenza B

Prevented infections

No vaccination

TIV

QIV

QIV-TIV

%

0%

8283

6552

4372

2180

17,9

(8224–8394)

(6477–6627)

(4313–4431)

(2142–2217)

(17,6-18,2)

10%

7557

5760

4009

1751

15,4

(7491–7649)

(5692–5827)

(3954–4063)

(1716–1786)

(15,1-15,7)

20%

6961

5140

3772

1368

12,7

(6890–7037)

(5079–5200)

(3720–3824)

(1336–1399)

(12,5-13,0)

30%

6491

4624

3574

1050

10,2

(6445–6587)

(4569–4680)

(3526–3623)

(1020–1080)

(10,0-10,5)

40%

6144

4216

3386

830

8,4

(6070–6206)

(4163–4269)

(3339–3433)

(801–859)

(8,1-8,7)

50%

5837

3865

3276

589

6,2

(5783–5916)

(3815–3914)

(3230–3322)

(562–615)

(5,9-6,5)

60%

5229

3346

2951

395

4.3

(5183–5275)

(3313–3379)

(2920–2982)

(376–414)

(4.1-4.5)

  1. Average annual results (with 95% confidence intervals) obtained for the 20 year evaluation period (calculated from 1,000 simulations for each combination of L and vaccination strategy in a simulated population of about 80,000 individuals (2,000 simulations each for the baseline parameter value L = 60%; boldface line). The last column shows what percentage of all influenza A and B infections which occur under TIV vaccination can additionally be prevented by QIV.