Molecular detection and characterization of resistant genes in Mycobacterium tuberculosis complex from DNA isolated from tuberculosis patients in the Eastern Cape province South Africa

Table 4 Frequency of mutations in rpoB gene codons 42, 52, 87, 92, 441, 450 and 457 in 140 RIF-resistant strains of M. tuberculosis complex

	rpoBgene mutation positions
	Y₄₂ → D	G₅₂ → A	H₈₇ → G	L₉₂ → S	V₄₄₁ → G	L₄₅₀ → S	L ₄₅₇ → P
No. of strains (%)	30 (21.4%)	20 (14.3%)	10 (7.1%)	10 (7.1%)	10 (7.1%)	10 (7.1%)	10 (7.1%)

Y = Tyrosine; D = Aspartic; G = Glycine; A = Alanine; H = Histidine; L = Leucine; S = Serine; V = Valine; P = Proline.

ISSN: 1471-2334