Skip to main content

Table 2 Incidence of HPV by male circumcision status

From: Male circumcision and the incidence and clearance of genital human papillomavirus (HPV) infection in men: the HPV Infection in men (HIM) cohort study

HPV Type

Uncircumcised men

Circumcised men

Log-rank test p

HR (95% CI) [circumcised versus uncircumcised]

No. Infections/No. PYs

Incidence per 100 PYs (95% CI)

% 12-month Incidence (95% CI)

No. Infections/No. PYs

Incidence per 100 PYs (95% CI)

% 12-month Incidence (95% CI)

Any HPV a

555/1098

50.5 (46.4, 54.9)

38.7 (35.5, 41.7)

359/788

45.6 (41, 50.5)

35.2 (31.4, 38.8)

0.29

0.93 (0.81-1.06)

Oncogenic b

584/2055

28.4 (26.2, 30.8)

23.7 (21.5, 25.9)

369/1285

28.7 (25.9, 31.8)

23.3 (20.5, 26)

0.64

1.03 (0.84-1.26)

16

204/3546

5.8 (5, 6.6)

5.1 (4.1, 6)

143/2164

6.6 (5.6, 7.8)

6.3 (4.9, 7.7)

0.15

1.17 (0.95-1.45)

18

97/3886

2.5 (2, 3)

1.9 (1.3, 2.5)

71/2421

2.9 (2.3, 3.7)

3.1 (2.1, 4)

0.24

1.20 (0.88-1.63)

31

71/3904

1.8 (1.4, 2.3)

1.6 (1.1, 2.2)

52/2462

2.1 (1.6, 2.8)

2 (1.2, 2.8)

0.40

1.17 (0.81-1.67)

33

24/4039

0.6 (0.4, 0.9)

0.4 (0.1, 0.6)

16/2532

0.6 (0.4, 1)

0.8 (0.3, 1.2)

0.86

1.06 (0.56-2.00)

35

44/3951

1.1 (0.8, 1.5)

0.8 (0.5, 1.2)

26/2492

1 (0.7, 1.5)

1 (0.5, 1.6)

0.83

0.95 (0.58-1.55)

39

106/3800

2.8 (2.3, 3.4)

2.6 (1.9, 3.3)

95/2358

4 (3.3, 4.9)

3.4 (2.3, 4.4)

0.01

1.47 (1.11-1.94)

45

94/3876

2.4 (2, 3)

1.8 (1.2, 2.4)

62/2451

2.5 (1.9, 3.2)

2.9 (1.9, 3.8)

0.70

1.06 (0.77-1.47)

51

187/3615

5.2 (4.5, 6)

4.5 (3.6, 5.5)

142/2160

6.6 (5.5, 7.7)

6.8 (5.4, 8.3)

0.02

1.30 (1.04-1.61)

52

164/3525

4.7 (4, 5.4)

5.4 (4.4, 6.4)

98/2277

4.3 (3.5, 5.2)

4.3 (3.1, 5.4)

0.80

0.97 (0.75-1.24)

56

79/3894

2 (1.6, 2.5)

2 (1.4, 2.7)

56/2443

2.3 (1.7, 3)

1.7 (0.9, 2.4)

0.40

1.16 (0.82-1.63)

58

104/3845

2.7 (2.2, 3.3)

2.5 (1.8, 3.1)

42/2467

1.7 (1.2, 2.3)

1.8 (1, 2.5)

0.01

0.61 (0.43-0.88)

59

165/3672

4.5 (3.8, 5.2)

3.9 (3.1, 4.8)

119/2223

5.4 (4.4, 6.4)

5 (3.7, 6.2)

0.14

1.19 (0.94-1.51)

68

143/3789

3.8 (3.2, 4.4)

3.9 (3, 4.7)

48/2393

2 (1.5, 2.7)

2.5 (1.6, 3.4)

<0.001

0.56 (0.40-0.78)

Non-oncogenic c

596/1497

39.8 (36.7, 43.1)

32.5 (29.7, 35.1)

372/1094

34 (30.6, 37.6)

28.9 (25.7, 32)

0.08

0.83 (0.69-1.00)

6

201/3553

5.7 (4.9, 6.5)

5.4 (4.4, 6.3)

104/2258

4.6 (3.8, 5.6)

3.9 (2.8, 5)

0.11

0.82 (0.65-1.04)

11

58/3961

1.5 (1.1, 1.9)

1.2 (0.7, 1.7)

25/2511

1 (0.6, 1.5)

1 (0.4, 1.5)

0.12

0.69 (0.43-1.10)

26

21/4050

0.5 (0.3, 0.8)

0.3 (0.1, 0.6)

6/2541

0.2 (0.1, 0.5)

0.5 (0.1, 0.8)

0.08

0.45 (0.18-1.12)

40

65/3941

1.6 (1.3, 2.1)

1.1 (0.6, 1.5)

44/2479

1.8 (1.3, 2.4)

1.7 (1, 2.4)

0.72

1.07 (0.73-1.58)

42

78/3914

2 (1.6, 2.5)

1.8 (1.2, 2.4)

29/2494

1.2 (0.8, 1.7)

0.8 (0.3, 1.3)

0.01

0.59 (0.38-0.90)

53

198/3630

5.5 (4.7, 6.3)

4.6 (3.7, 5.6)

110/2276

4.8 (4, 5.8)

4.4 (3.2, 5.5)

0.34

0.89 (0.71-1.13)

54

135/3815

3.5 (3, 4.2)

3.8 (2.9, 4.6)

90/2390

3.8 (3, 4.6)

3.6 (2.5, 4.6)

0.56

1.08 (0.83-1.42)

55

85/3873

2.2 (1.8, 2.7)

1.8 (1.2, 2.4)

66/2434

2.7 (2.1, 3.4)

2.5 (1.6, 3.3)

0.16

1.26 (0.91-1.74)

61

177/3628

4.9 (4.2, 5.7)

5 (4, 5.9)

68/2437

2.8 (2.2, 3.5)

3.2 (2.2, 4.2)

<0.001

0.59 (0.44-0.78)

62

199/3482

5.7 (4.9, 6.6)

5.6 (4.6, 6.6)

120/2231

5.4 (4.5, 6.4)

5.3 (4, 6.6)

0.69

0.95 (0.76-1.20)

64

11/4067

0.3 (0.1, 0.5)

0.2 (0, 0.4)

3/2557

0.1 (0, 0.3)

0.1 (0, 0.2)

0.18

0.43 (0.12-1.53)

66

150/3708

4 (3.4, 4.7)

3.8 (2.9, 4.6)

112/2261

5 (4.1, 6)

5.5 (4.2, 6.8)

0.08

1.25 (0.98-1.60)

67

42/4020

1 (0.8, 1.4)

0.9 (0.5, 1.3)

22/2528

0.9 (0.5, 1.3)

0.8 (0.3, 1.3)

0.59

0.87 (0.52-1.45)

69

9/4061

0.2 (0.1, 0.4)

0.1 (0, 0.2)

4/2556

0.2 (0, 0.4)

0.1 (0, 0.2)

0.60

0.73 (0.22-2.37)

70

85/3872

2.2 (1.8, 2.7)

2.3 (1.6, 2.9)

41/2467

1.7 (1.2, 2.3)

1.8 (1, 2.5)

0.20

0.78 (0.54-1.14)

71

64/3921

1.6 (1.3, 2.1)

1.7 (1.1, 2.3)

15/2531

0.6 (0.3, 1)

0.7 (0.2, 1.2)

<0.001

0.37 (0.21-0.65)

72

63/3928

1.6 (1.2, 2.1)

1.6 (1.1, 2.2)

31/2503

1.2 (0.8, 1.8)

1.3 (0.7, 2)

0.31

0.80 (0.52-1.23)

73

70/3923

1.8 (1.4, 2.3)

1.5 (1, 2)

41/2478

1.7 (1.2, 2.2)

1.6 (0.9, 2.3)

0.71

0.93 (0.63-1.37)

81

113/3774

3 (2.5, 3.6)

3.2 (2.4, 3.9)

49/2447

2 (1.5, 2.6)

2.1 (1.3, 2.8)

0.04

0.70 (0.50-0.98)

82

43/4022

1.1 (0.8, 1.4)

0.7 (0.4, 1.1)

34/2487

1.4 (0.9, 1.9)

1.5 (0.8, 2.1)

0.35

1.24 (0.79-1.95)

83

78/3864

2 (1.6, 2.5)

2 (1.4, 2.6)

45/2453

1.8 (1.3, 2.5)

1.7 (1, 2.4)

0.60

0.91 (0.63-1.31)

84

225/3516

6.4 (5.6, 7.3)

6 (4.9, 7)

163/2125

7.7 (6.5, 8.9)

7.6 (6.1, 9.1)

0.09

1.19 (0.97-1.46)

89

215/3564

6 (5.3, 6.9)

5.9 (4.8, 6.9)

140/2202

6.4 (5.3, 7.5)

5.7 (4.3, 7)

0.51

1.07 (0.87-1.33)

IS39

35/4004

0.9 (0.6, 1.2)

0.6 (0.3, 1)

9/2543

0.4 (0.2, 0.7)

0.2 (0, 0.5)

0.01

0.41 (0.20-0.86)

  1. aAny HPV was defined as at least one of 37 HPV genotypes;
  2. bOncogenic HPV types: 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, 59, and 68;
  3. cNon-oncogenic HPV types: 6, 11, 26, 40, 42, 53, 54, 55, 61, 62, 64, 66, 67, 69, 70, 71, 72, 73, 81, 82, 83, 84, 89 (CP6108), and IS39;
  4. NOTE: PY, person-year; HR, hazard ratio; CI, confidence interval.
Back to article page

BMC Infectious Diseases

ISSN: 1471-2334

Contact us