Sex- and age-dependent association of SLC11A1polymorphisms with tuberculosis in Chinese: a case control study

BMC Infectious Diseases

Table 2 Relation between markers SLC6a/b and tuberculosis in Chinese stratified by sex or age^a

Alleles/genotypes	TB patients		Control subjects		Odds ratio (95% CI)	Pvalue
Comparison of allele frequencies
*Stratification by sex*
Male
G-TGTG	352	(85%)	366	(88%)	1
A- ----	62	(15%)	52	(12%)	1.24 (0.83 – 1.84)	0.2876
Female
G-TGTG	110	(78%)	131	(90%)	1
A- ----	32	(22%)	15	(10%)	2.54 (1.31 – 4.93)	0.0049 ^b
*Stratification by age*
Age ≤65
G-TGTG	198	(86%)	218	(94%)	1
A- ----	32	(14%)	14	(6%)	2.52 (1.31 – 4.85)	0.0047 ^b
Age >65
G-TGTG	264	(81%)	279	(84%)	1
A- ----	62	(19%)	53	(16%)	1.24 (0.83 – 1.85)	0.3023
Comparison of genotype frequencies ^c
*Stratification by sex*
Male
G-TGTG/G-TGTG	149	(72%)	161	(77%)	1
A- ----/-	58	(28%)	48	(23%)	1.31 (0.84 – 2.03)	0.2370
Female
G-TGTG/G-TGTG	43	(61%)	59	(81%)	1
A- ----/-	28	(39%)	14	(19%)	2.74 (1.29 – 5.82)	0.0075 ^b
*Stratification by age*
Age ≤65
G-TGTG/G-TGTG	86	(75%)	104	(90%)	1
A- ----/-	29	(25%)	12	(10%)	2.92 (1.41 – 6.07)	0.0031 ^b
Age >65
G-TGTG/G-TGTG	106	(65%)	116	(70%)	1
A- ----/-	57	(35%)	50	(30%)	1.25 (0.79 – 1.989)	0.3479

^a Markers SLC6a and SLC6b are in perfect LD and thus are analyzed as a single marker (SLC6a/b).
^b Significant even after correction of multiple testing based on false discovery rate at a level of 0.05. The adjusted cut-off P value is 0.0250 for eight comparisons. For details, see additional file 1.
^c The genotype A- ----/- stands for either A- ----/G-TGTG or A- ----/A- ----.

ISSN: 1471-2334