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Table 2 Factors associated with virological response (univariate and multivariate analyses).

From: Predictive factors of virological success to salvage regimens containing protease inhibitors in HIV-1 infected children

  Univariate analysis Multivariate analysis
  OR (95% CI) p OR (95% CI)  
Rescue with PI/rit 3.93 (0.88 to 17.56) 0.07 7.57 (0.58 to 99.31) 0.12
Previous length of ARV exposure 0.99 (0.97 to 1.01) 0.29 - -
Previous length of PI exposure 0.98 (0.94 to 1.01) 0.19 - -
No. previous PIs exposure 0.61 (0.29 to 1.25) 0.18 0.23 (0.06 to 0.89) 0.03
No. susceptible drugs according to CCO1 2.16 (1.02 to 4.57) 0.04 0.22 (0.03 to 1.57) 0.13
No. susceptible drugs according to CCO2 4.99 (1.55 to 16.05) 0.01 5.34 (1.23 to 23.11) 0.02
No. active PIs in the salvage regimen according to virtual phenotype 6.60 (1.40 to 31.05) 0.02 0.64 (0.03 to 11.58) 0.76
No. NAMs 0.85 (0.54 to 1.32) 0.46 - -
No. protease resistance mutations 0.81 (0.62 to 1.06) 0.12 0.89 (0.56 to 1.46) 0.65
  1. (OR: Odds ratio; PI: protease inhibitor; RIT: ritonavir; ARV: antiretroviral treatment; CC01: lower clinical cut-off; CC02: upper clinical cut-off; NAMs: nucleotide analogue mutations: M41L, D67N, K70R, L210W, T215Y/F y K219Q/E/R/S/N)