Low-level HIV-1 replication and the dynamics of the resting CD4+T cell reservoir for HIV-1 in the setting of HAART

Table 1 Parameter values used for simultations and calculations

Parameter	Definition	Values^a	References
δ _P	Net death rate of productively infected cells	0.50 (0.5–0.693) day^-1	[32, 65, 66]
δ _L ^b	Net death rate of latently infected cells	0.0001 (0.001–0.0001) day^-1	[32]
δ _U	Net death rate of target cells	0.02 (1.0–0.001) day^-1	[32, 67]
α _Q	Activation rate of latently infected cells	0.0005 (0.001–0.0001) day^-1	[36]
α _R ^c	Rate of reversion of productively infected cells to latency	$\frac{α_{Q}}{100}$	[3, 32, 68, 69]
λ	Production rate of target cells	2 × 10⁹ cells/day	Approximated from the steady-state condition that $\bar{U}$ = 1 × 10¹¹ in the case of no infection. Also consistent with [70]
$\frac{L}{\bar{U}}$	Ratio of latently infected cells to target cells	10^-4 (10^-4–10^-6)	[2, 4]

^aRanges tested in parentheses
^bEstimated based on resting cell death rate
^cEstimated based on the ratio of latently infected cells to productively infected cells

ISSN: 1471-2334