Recreational drug use and risks of HIV and sexually transmitted infections among Chinese men who have sex with men: Mediation through multiple sexual partnerships

Table 3 The mediation effect of unprotected anal sex on recreational drug use and HIV/STIs infection of MSM

Variables	X → M	M → Y	X → Y	(X, M) → Y
Variables	aOR(95% CI) ^#	aOR(95% CI) ^#	aOR(95% CI) ^#	aOR(95% CI) ^#
Outcome: HIV infection (Y)
Drug use (X)	1.25(1.05,1.49)*	N/A	1.67(1.31,2.13)	1.69(1.32, 2.15)**
Unprotected sex (M)	N/A	0.81(0.63,1.03)	N/A	0.77(0.61,0.99)*
Outcome: syphilis infection (Y)
Drug use (X)	1.25(1.05,1.49)*	N/A	1.61(1.29, 2.00)**	1.62(1.30, 2.02)**
Unprotected sex (M)	N/A	0.84(0,67,1.04)	N/A	0.82(0.65,1.02)
Outcome: HSV-2 infection (Y)
Drug use (X)	1.25(1.05,1.49)*	N/A	0.96(0.75,1.24)	0.96(0.75,1.24)
Unprotected sex (M)	N/A	0.99(0.77,1.26)	N/A	0.98(0.77, 1.25)

Notes: STIs: sexually transmitted infections; MSM: men who have sex with men; HSV-2: herpes simplex type 2; N/A: not applicable; X: exposure variable;, Y: outcome variable;, M: mediator.; aOR: adjusted odds ratio; CI: confidence interval.
^#All multivariate regression models are controlled for the covariates which are significant in bivariate analyses in Table 1, including age, marital status, monthly income and HIV knowledge. *p < 0.05, **p < 0.01.

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