Table 4 Subgroup and sensitivity analyses

Overall

35

11.4

9.3

13.5

0.004

44

Daily culture

5

10.8

4.8

16.8

0.16

39

Culture when indicated

15

11.2

8.6

13.9

0.16

27

Other culture regimes

15

13.5

9.6

17.4

0.048

41

Culture proven infection

18

11.5

8.4

14.6

0.004

54

CDC definition of infection

5

8.8

6.3

11.3

0.403

0.50

Culture plus other features

5

9.1

4.8

13.4

0.436

0

Culture or other features

7

17

10

24.1

0.347

11

Age group

Paediatric

3

10.6

6.1

15.2

0.429

0

Adult

32

11.5

9.3

13.7

0.002

48

Year

Publication year <2000

5

18.3

12.4

24.3

0.39

3

Publication year 2000+

30

10.5

8.4

12.6

0.002

47

Duration

Mean duration <7 days

6

19.6

10

24.1

0.6

0

Mean duration 7-10 days

14

12.8

9.5

16

0.03

49

Mean duration >10 days

15

8

5.4

10.5

0.106

37

Study type

Prospective

5

11

6.6

15.4

0.23

29

Retrospective

30

11.4

9.1

13.8

0.003

47

AIC

No AIC

18

10.8

8.1

13.6

0.001

57

Unclear

13

13.7

9.8

17.6

0.19

25

AIC used

4

7.2

2.6

14.1

0.64

0

Study size

<=1000 catheter-days

13

18.3

13.4

23.3

0.34

11

>1000 catheter-days

22

9

6.8

11.2

0.027

40

1 and 2

11

13.5

8.9

18.1

0.046

46

3 and 4

24

10.6

8.3

13

0.019

41