Table 3 Treatment of localized candidiasis

Pyelonephritis

Fluconazole 200–400 mg for 14 days

Amphotericin B deoxycholate 0.5-0.7 mg/kg daily +/− flucytosine 25 mg/kg four times daily or flucytosine alone for 14 days

Osteomyelitis

Fluconazole 400 mg daily for 6–12 months

Echinocandin* or Amphotericin B deoxycholate 0.5-1 mg/kg daily for several weeks and then fluconazole for 6–12 months

Lipid formulations of amphotericin B 3–5 mg/kg daily for several weeks, then fluconazole for 6–12 months

Septic arthritis

Fluconazole 400 mg daily for at least 6 weeks

Echinocandin* or Amphotericin B deoxycholate 0.5-1 mg/kg daily for several weeks and then fluconazole

Lipid formulations of amphotericin B 3–5 mg/kg daily for several weeks, then followed by fluconazole

CNS candidiasis

Lipid formulations of amphotericin B 3–5 mg/kg +/− flucytosine 25 mg/kg four times daily for several weeks, followed by fluconazole 400–800 mg daily until the resolution of symptoms

Fluconazole 400–800 mg daily for patients intolerant to lipid formulations of amphotericin B

Endophthalmitis

Amphotericin B deoxycholate 0.7-1 mg/kg with flucytosine 25 mg/kg four times daily for at least 4–6 weeks along with surgical intervention for severe cases

Lipid formulations of amphotericin B 3–5 mg/kg daily

Voriconazole 6 mg/kg twice daily for two doses, then 3–4 mg/kg twice daily

Echinocandin*

Endocarditis

Lipid formulations of amphotericin B 3–5 mg/kg +/− flucytosine 25 mg/kg four times daily

Valve replacement is strongly recommended, otherwise chronic suppression with fluconazole 400–800 mg daily is recommended. Lifelong suppressive therapy for prosthetic valve endocarditis if valve cannot be replaced is recommended.

Amphotericin B deoxycholate 0.6-1 mg/kg +/− flucytosine 25 mg/kg four times daily

Echinocandin**