Patient characteristics | Number of casesa(%) (N = 1210) | Median number of days between onset of symptoms and collection of specimen (IQR) (in days) | Change in time difference between onset of symptoms and collection of specimen | |||
---|---|---|---|---|---|---|
Unadjusted (95 % C1) (in days) | P-value of LRTb | Adjusted (95 % CI) (in days) No of observations - 886 | P-value of LRTb | |||
Age | ||||||
0–9 years | 7 (0.6) | 2 (1 to 18) | 0 | 0.18 | 0 | 0.08 |
10–29 years | 32 (2.6) | 2 (0 to 5) | −2.5 (−11.6 to 6.5) | −3.1 (−15.3 to 9.2) | ||
30–49 years | 103 (8.5) | 2 (0 to 5) | −1.8 (−10.7 to 7.1) | −4.5 (−16.6 to 7.5) | ||
50–69 years | 448 (37.0) | 2 (0 to 5) | −2.9 (−11.7 to 5.8) | −4.4 (−16.3 to 7.5) | ||
70+ years | 620 (51.2) | 1 (0 to 4) | −2.5 (−11.2 to 6.2) | −3.6 (−15.6 to 8.2) | ||
Gender | ||||||
Females | 537 (44.4) | 2 (0 to 4) | 0 | 0.77 | 0 | 0.27 |
Males | 673 (55.6) | 1 (0 to 4) | +0.1 (−0.8 to 0.9) | +0.3 (−0.5 to 1.2) | ||
Ethnicity | ||||||
White British | 1057 (87.4) | 1 (0 to 4) | 0 | 0.24 | 0 | 0.11 |
Others | 153 (12.6) | 2 (1 to 5) | +0.5 (−0.9 to 1.9) | +0.8 (−0.6 to 2.3) | ||
Deprivation | ||||||
1 (least) | 224 (18.6) | 1.5 (0 to 4) | 0 | 0.05 | 0 | 0.02 |
2 | 235 (19.5) | 2 (1 to 4) | +0.2 (−0.9 to 1.5) | −0.1 (−1.2 to 1.0) | ||
3 | 229 (19.1) | 2 (0 to 5) | +1.1 (−0.3 to 2.4) | +1.2 (−0.2 to 2.7) | ||
4 | 260 (21.6) | 1 (0 to 4) | +1.1 (−0.2 to 2.5) | +1.0 (−0.3 to 2.3) | ||
5 (most) | 255 (21.2) | 2 (0 to 5) | +0.7 (−0.5 to 2.0) | +0.7 (−0.5 to 2.0) | ||
Unknown | 7 | |||||
Serogroup | ||||||
1/2a | 341 (32.8) | 1 (0 to 4) | 0 | <0.001 | 0 | <0.003 |
1/2b | 97 (9.3) | 1 (0 to 3) | −1.3 (−2.7 to −0.6) | −1.5 (−2.7 to −0.3) | ||
1/2c | 36 (3.5) | 1 (0 to 4.5) | −0.9 (−3.0 to 1.2) | −0.6 (−2.5 to 1.2) | ||
4 | 566 (54.4) | 2 (0 to 5) | +0.6 (−0.4 to 1.6) | +0.2 (−0.7 to 1.2) | ||
Unknown | 170 | |||||
Underlying condition | ||||||
Absent | 168 (15.1) | 2 (1 to 5) | 0 | <0.002 | 0 | 0.001 |
Present | 942 (84.9) | 1 (0 to 4) | −1.3 (−2.8 to 0.2) | −1.5 (−3.1 to −0.03) | ||
Unknown | 100 | |||||
Presenting illness | ||||||
Other illness | 91 (8.1) | 2 (0 to 6) | 0 | <0.001 | 0 | <0.001 |
Gastroenteritis | 46 (4.1) | 1 (0 to 6) | +0.8 (−2.8 to 4.5) | +.2.7 (−1.5 to 7.1) | ||
Meningitis | 140 (12.4) | 2 (1 to 5) | −0.8 (−3.1 to 1.6) | −0.7 (−3.1 to 1.6) | ||
Septicaemia | 618 (54.8) | 1 (0 to 4) | −1.5 (−3.6 to 0.4) | −0.8 (−2.8 to 1.2) | ||
Septicaemia and Gastroenteritis | 83 (7.4) | 2 (0 to 6) | +0.1 (−2.7 to 2.9) | +0.4 (−2.2 to 3.2) | ||
Meningitis and Septicaemia | 143 (12.7) | 2 (0 to 3) | −2.4 (−4.5 to −0.2) | −1.7 (−3.8 to 0.4) | ||
Meningitis and Septicaemia and Gastroenteritis | 7 (0.6) | 6 (4 to 10) | +1.2 (−7.4 to 9.9) | +2.2 (−6.5 to 11.1) | ||
82 | ||||||
Survival | ||||||
Alive | 768 (66.7) | 2 (0 to 4) | 0 | 0.52 | 0 | 0.76 |
Died | 383 (33.3) | 1 (0 to 4) | −0.2 (−1.2 to 0.8) | +0.1 (−0.8 to 1.0) | ||
Unknown | 59 |