| Anidulafungin | Micafungin | P |
---|---|---|---|
(n = 30) | (n = 33) | ||
On admission | |||
 Age (years) | 59 (20) | 62 (20) | 0.36 |
 Gender (male)a | 19 (63) | 26 (79) | 0.18 |
 APACHE II score | 26 (10) | 23 (8) | 0.13 |
 SOFA score | 10 (9) | 9 (3) | 0.63 |
 Reasons of ICU admissiona |  |  | 0.14 |
  Suspected sepsis | 9 (30) | 11 (33) |  |
  Respiratory failure | 2 (7) | 6 (19) |  |
  Renal failure | 1 (3) | 0 (0) |  |
  Liver failure | 4 (13) | 0 (0) |  |
  CPR | 2 (7) | 2 (6) |  |
  Shock | 5 (17) | 3 (10) |  |
  Postoperative | 7 (23) | 11 (34) |  |
At start of echinocandin | |||
 Risk factors for invasive candidiasisa | |||
 Neutropenia | 3 (10) | 2 (6) | 0.57 |
 Broad spectrum antibiotics | 18 (60) | 15 (45) | 0.25 |
 Immunosuppression | 4 (13) | 3 (9) | 0.60 |
 Steroids | 16 (53) | 12 (36) | 0.18 |
 TPN | 4 (13) | 11 (33) | 0.07 |
 Recent Surgery | 8 (27) | 15 (45) | 0.13 |
 DM II | 11 (37) | 7 (21) | 0.18 |
 Malignancy | 5 (17) | 11 (33) | 0.13 |
 Transplant | 5 (17) | 4 (12) | 0.61 |
 CVVH | 19 (63) | 7 (21) | 0.001 |
 CVC | 29 (97) | 29 (88) | 0.20 |
 Mechanical ventilation | 27 (90) | 32 (97) | 0.26 |
Duration between admission and start echinocandin (days) | 3 (4) | 2 (2) | 0.17 |