Table 1 Baseline characteristics of the Mannheim Sepsis Study (MaSep) at day 1

Age, years (mean, range)

64 (42–87)

65 (26–88)

67 (39–87)

0.9

Gender, n (%)

 Male

42 (55)

47 (64)

101 (72)

<0.001

 Female

35 (45)

26 (36)

39 (28)

0.1

 Lung

-

47 (64)

84 (60)

0.001

 Urinary tract

-

9 (12)

12 (8)

0.5

 Abdominal

-

10 (14)

15 (11)

0.3

 Central nervous system

-

0 (0)

0 (0)

-

 Skin

-

2 (3)

8 (6)

0.06

 Heart

-

4 (6)

4 (3)

1.0

 Blood

-

1 (1)

10 (7)

0.007

 Others

-

0 (0)

7 (5)

-

 White blood cells (10⁹/L)

-

16.1 ± 1.4

18.1 ± 1.2

0.4

 Platelets, (10E9/L)

-

221 ± 16.2

169 ± 9.9

0.01

 Bilirubin, mg/dl

-

1.6 ± 0.4

3 ± 0.6

0.004

 Lactate mg/dl

-

2.3 ± 0.2

3.5 ± 0.3

0.002

 Creatinine, mg/dl

-

2.4 ± 0.2

2.8 ± 0.2

0.05

 C reactive proteine, mg/l

-

186 ± 12.5

207 ± 9.5

0.2

 Procalcitonin, ng/ml

-

12.5 ± 2.7

31 ± 5.7

0.002

 Interleukin 6, pg/ml

-

16,281 ± 15,560

6802 ± 1911

<0.001

 pCO2 (mmHg)

-

37.9 ± 1.6

43.7 ± 1.6

0.02

 Positive blood cultures, n (%)

-

28 (38)

62 (44)

<0.001

 ICU days

-

10 ± 1.1

14.6 ± 1.3

0.1

 Ventilation days

-

4.3 ± 0.9

9.4 ± 1.1

<0.001

 Catecholamine days

-

2 ± 0.5

7.4 ± 0.6

<0.001

 Renal replacement therapy days

-

1 ± 0.3

4.2 ± 0.7

<0.001

APACHE II, mean ± SEM

-

20.5 ± 0.9

27.6 ± 0.6

<0.001

SOFA score, mean ± SEM

-

7.2 ± 0.4

12.3 ± 0.3

<0.001