Table 2 Final case categorisation, based on laboratory features
From: The aetiologies of central nervous system infections in hospitalised Cambodian children
CNS infection category | Features (in addition to meeting clinical case definition) |
|---|---|
Suspected | Non-purulent CSF AND absence of identifiable pathogens by culture, PCR, or serology |
Probable | Purulent CSF (WBC ≥100 cells/μL OR [WBC 10–99 cells/μL AND glucose <2.2 mmol/L or protein >1.0 g/L]) AND absence of identifiable pathogens by culture, Gram stain, PCR, or serologya OR Abnormal CSF (WBC 10–99 cells/μL AND normal protein/glucose) AND positive blood culture and/or positive CSF Gram stain |
Confirmed | Pathogen detected in CSF by culture and/or PCR OR Positive serology in CSF OR Positive blood culture AND purulent CSF OR Purulent CSF AND positive CSF Gram stain |