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Table 1 Characteristics of 23 published studies included for meta-analysis and the primary results of Xpert MTB/RIF test

From: Is Xpert MTB/RIF appropriate for diagnosing tuberculous pleurisy with pleural fluid samples? A systematic review

First author Year Country Patients enrolled Mean age (years)a HIV-infection prevalence (%) Specimen types Reference standard Results
TP FP FN TN
Causse 2011 Spain 34 45(5–83) NR Pleural fluid Culture 4 0 0 30
Friedrich 2011 South Africa 25 NR NR Pleural fluid Culture 5 0 15 5
Malbruny 2011 France 12 52 4.3% Pleural fluid Culture 0 0 2 10
Moure 2012 Spain 31 NR NR Pleural fluid Culture 7 0 19 5
Tortoli 2012 Italy 330 NR NR Pleural fluid Culture 5 3 10 312
Christopher 2013 India 91 46(33–57) NR Pleural fluid Culture and biopsy 4 0 26 61
Porcel 2013 Spain 67 50 0% Pleural fluid Culture and biopsy 5 0 28 34
Zmak 2013 Croatia 42 NR NR Pleural fluid Culture 0 0 1 41
Javed 2014 Pakistan 25 NR NR Pleural fluid Biopsy 2 0 12 11
Lusiba 2014 Uganda 116 34 ± 13 44.8% Pleural fluid Culture and biopsy 25 1 62 28
Meldau 2014 South Africa 88 51 10.2% Pleural fluid Culture and biopsy 9 1 31 47
Scott 2014 South Africa 528 39 NR Pleural fluid Culture 227 3 255 43
Sharma SK 2014 India 364 NR NR Pleural fluid Culture 37 8 54 265
Theron 2014 South Africa 76 55(38–65) 17% Pleural fluid Culture 5 6 11 54
Trajman 2014 Brazil 59 50 5% Pleural fluid Culture and biopsy 1 0 32 26
Coleman 2015 Malawi 50 32 100% Pleural fluid Culture 9 0 4 18
Liu 2015 China 126 38.6 ± 13.2 4.0% Pleural fluid Culture 24 1 31 70
Rufai 2015 India 162 41.6 ± 19 0% Pleural fluid Culture 23 0 19 119
Wang 2015 China 125 43 NR Pleural fluid Culture 13 47 0 65
Che 2017 China 78 44 (18–83) 1.3% Pleural fluid Culture and biopsy 12 0 48 18
Li 2018 China 70 42 ± 20 0% Pleural fluid Culture and biopsy 6 0 39 25
Sharma S 2018 India 37 39 0% Pleural fluid Culture and biopsy 5 0 2 30
Christopher 2018 India 130 50.9 ± 14.1 0% Pleural fluid Biopsy 9 0 56 65
  1. TP, true positive. FP, false positive. FN, false negative. TN, true negative. NR, not reported in the study
  2. a The values represent the means±SD or medians with corresponding interquartile ranges (IQRs)