AIDS-related opportunistic illnesses and early initiation of HIV care remain critical in the contemporary HAART era: a retrospective cohort study in Taiwan

Table 3 Cox regression hazards model for factors predicting all-cause mortality in 1264 newly diagnosed HIV infection

	Univariable analysis		Multivariable analysis^a
	HR (95% CI)	P	AHR (95% CI)	P
Age, per 10-year increase	2.00 (1.71–2.32)	< 0.001	1.47 (1.21–1.77)	< 0.001
Male sex	1.09 (0.15–7.86)	0.93	3.67 (0.48–28.34)	0.21
HIV transmission route
Homosexual	1.00 (Reference)		1.00 (Reference)
Heterosexual	5.38 (3.03–9.55)	< 0.001	2.61 (1.32–5.16)	0.006
Bisexual	2.67 (1.03–6.90)	0.043	1.86 (0.71–4.88)	0.21
IDU	2.64 (0.36–19.38)	0.34	1.98 (0.26–14.98)	0.51
Unknown	11.14 (2.65–46.78)	0.001	5.87 (1.27–27.08)	0.011
Period
Period 1	1.00 (Reference)
Period 2	1.32 (0.72–2.43)	0.37	1.48 (0.80–2.76)	0.21
Period 3	0.71 (0.34–1.48)	0.35	0.92 (0.43–1.95)	0.82
Subgroup of CD4 cell count at presentation	17.59 (7.02–44.07)	< 0.001
CD4 count ≥500 cells/μL	1.00 (Reference)		1.00 (Reference)
CD4 count 200–499 cells/μL	1.29 (0.15–11.03)	0.82	1.21 (0.14–10.42)	0.86
CD4 count < 200 cells/μL	16.86 (2.33–122.04)	0.005	11.03 (1.51–80.64)	0.018
HBsAg seropositivity	3.30 (1.80–6.05)	< 0.001	2.65 (1.42–4.94)	0.002

Abbreviations: AHR adjusted hazard ratio, AOIs AIDS-defining opportunistic illnesses, CI confidence interval, HBsAg hepatitis B surface antigen, HCV hepatitis C virus, HR hazard ratio, IDU intravenous drug users
^aAll variables in the univariate analysis were selected for subsequent multivariate analysis

ISSN: 1471-2334