Table 3 Univariable and multivariable analyses of factors associated with mortality for patients on ART at start of TB treatment
From: HIV and TB co-infection in the ART era: CD4 count distributions and TB case fatality in Cape Town
PYRS | Deaths | Univariable | Multivariable | |||
|---|---|---|---|---|---|---|
Characteristic | HR (95% CI) | P-value | aHR (95% CI) | P-value | ||
Calendar year | ||||||
2009 | 11,479 | 1400 | 1 | 1 | ||
2010 | 11,646 | 1275 | 1.11 (0.81–1.51) | 0.51 | 1.18 (0.85–1.63) | 0.32 |
2011 | 11,350 | 1135 | 1.06 (0.79–1.42) | 0.71 | 1.17 (0.86–1.59) | 0.32 |
2012 | 11,095 | 1099 | 0.95 (0.72–1.26) | 0.74 | 1.07 (0.80–1.44) | 0.64 |
2013 | 10,010 | 922 | 0.90 (0.68–1.20) | 0.47 | 1.05 (0.77–1.42) | 0.76 |
Age (per 10 years increase) | 5581 | 634 | 1.27 (1.17–1.38) | < 0.001 | 1.28 (1.17–1.40) | < 0.001 |
Female gender | 3232 | 329 | 1 | 1 | ||
Male gender | 2349 | 305 | 1.28 (1.09–1.50) | 0.002 | 1.02 (0.86–1.20) | 0.84 |
Re-treatment TB | 2606 | 340 | 1 | 1 | ||
New TB | 2975 | 294 | 0.72 (0.61–0.83) | < 0.001 | 0.71 (0.61–0.84) | < 0.001 |
PTB | 4411 | 494 | 1 | 1 | ||
EPTB | 1170 | 140 | 1.06 (0.88–1.28) | 0.56 | 1.05 (0.86–1.27) | 0.43 |
CD4 (per increase of 50 cells/mm3) | 5389 | 603 | 1 0.87 (0.84–0.89) | < 0.001 | 1 0.87 (0.84–0.89) | P < 0.001 |