Table 1 Baseline characteristics stratified by the first endpoint (adverse outcome)
Factor | Level | Total | Non-adverse outcome at 30d | Adverse outcome at 30d | p-value |
|---|---|---|---|---|---|
N | 278 | 249 (89.6%) | 29 (10.4%) | ||
Demographics | |||||
Age in years median (IQR) | 71.5 (57, 82) | 71 (57, 82) | 76 (67, 83) | 0.078 | |
Gender, n (%) | Male | 165 (59.4%) | 147 (59.0%) | 18 (62.1%) | 0.75 |
Female | 113 (40.6%) | 102 (41.0%) | 11 (37.9%) | ||
BMI, median (IQR) | 24.8 (22.0, 27.7) | 24.6 (21.8, 27.5) | 26.6 (24.4, 29.5) | 0.053 | |
Comorbidities | |||||
Coronary Heart Disease, n (%) | 52 (18.7%) | 44 (17.7%) | 8 (27.6%) | 0.2 | |
Congestive Heart Failure, n (%) | 35 (12.6%) | 31 (12.4%) | 4 (13.8%) | 0.84 | |
Chronic Kidney Disease, n (%) | 67 (24.1%) | 51 (20.5%) | 16 (55.2%) | < 0.001 | |
Diabetes mellitus, n (%) | 41 (14.7%) | 36 (14.5%) | 5 (17.2%) | 0.69 | |
Tumor, n (%) | 33 (11.9%) | 27 (10.8%) | 6 (20.7%) | 0.12 | |
COPD, n (%) | 73 (26.3%) | 61 (24.5%) | 12 (41.4%) | 0.051 | |
Vital signs | |||||
Pulse rate, bpm, median (IQR) | 94 (82, 107) | 94 (82.5, 106) | 97 (75, 114) | 0.75 | |
Temperature, °C, median (IQR) | 38 (37.2, 38.9) | 38 (37.2, 39) | 37.4 (36.7, 38.4) | 0.014 | |
Systolic BP, mmHg, median (IQR) | 130 (118, 146) | 131 (120, 147) | 124 (102, 139) | 0.044 | |
Clinical scores | |||||
PSI-Score | 1, 2 | 73 (26.3%) | 70 (28.1%) | 3 (10.3%) | < 0.001 |
3 | 56 (20.1%) | 55 (22.1%) | 1 (3.4%) | ||
4, 5 | 149 (53.6%) | 124 (49.8%) | 25 (86.2%) | ||
CURB-65-Score | 0, 1 | 125 (45.0%) | 120 (48.2%) | 5 (17.2%) | < 0.001 |
2, 3 | 139 (50.0%) | 123 (49.4%) | 16 (55.2%) | ||
4, 5 | 14 (5.0%) | 6 (2.4%) | 8 (27.6%) | ||
Markers of oxidative stress and inflammation | |||||
Tyrosine, median (IQR) | 81.7 (63.2, 118.0) | 81.6 (61.8, 117.0) | 84.0 (66.4, 122.0) | 0.33 | |
Tyr-NO2, median (IQR) | 1.5 (0.8, 11.7) | 1.5 (0.9, 12.3) | 1.4 (0.5, 4.0) | 0.29 | |
Ratio Tyr-NO2/Tyrosine, median (IQR) | 2.0 (1.0, 7.6) | 2.1 (1.0, 8.3) | 1.9 (0.9, 3.5) | 0.19 | |
CRP, median (IQR) | 136 (63, 252) | 132 (61, 246) | 176 (106, 336) | 0.032 | |
PCT, median (IQR) | 0.45 (0.16, 3.20) | 0.40 (0.15, 2.96) | 0.64 (0.21, 6.30) | 0.13 | |