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Table 3 Comparison of concentrations of five cytokines between participants with and without poor prognostic factors (N = 27)

From: Multiplex cytokine analysis in Mycobacterium avium complex lung disease: relationship between CXCL10 and poor prognostic factors

Cytokine/GF protein (pg/mL) Poor prognostic factors Low High * P-value
G-CSF BMI 19.6 (16–42.5) N/A NS
min LOD: 16 Alb 54.8 (25.8–70.1) N/A NS
max LOD: 10000 CRP N/A 21.5 (16–66.7) NS
  Hb 35.6 (16–125.8) N/A NS
IL-1RA BMI 28.2 (10.5–63.9) 17.4 (3.2–24.9) NS
min LOD: 3.2 Alb 43.2 (22.5–144.4) 19.6 (3.2–30.1) < 0.05
max LOD 10000 CRP 15.5 (3.2–46.2) 29.1 (17.3–43.2) NS
  Hb 29.1 (12.9–38.0) 19.6 (3.2–57.5) NS
IL-10 BMI 1.0 (0.64–4.2) 1.3 (0.64–2.9) NS
min LOD: 0.64 Alb 2.0 (0.9–18.6) 0.7 (0.64–3.6) NS
max LOD: 10000 CRP N/A 1.3 (0.64–4.0) NS
  Hb 1.3 (0.64–18.6) 0.7 (0.64–2.6) NS
CXCL10 BMI 953 (429–1568) 359 (226–456) 0.005
min LOD: 3.2 Alb 1030 (774–1816) 449 (274–554) < 0.005
max LOD: 10000 CRP 445 (263–592) 551 (367–1030) NS
  Hb 622 (286–1103) 455 (339–593) NS
sCD40L BMI 5941 (4235–10,000) 5278 (2808–7197) NS
min LOD: 0.64 Alb 7611 (4739–10,000) 5317 (3973–8380) NS
max LOD: 10000 CRP 4866 (3948–6210) 6323 (4300–10,000) NS
  Hb 5845 (3812–10,000) 5678 (3973–9481) NS
  1. Data are presented as median (interquartile range). Items with more than half cases below or over the LOD were excluded
  2. Abbreviations, GF growth factor, LOD limit of detection, G-CSF granulocyte colony-stimulating factor, BMI body mass index, Alb albumin, CRP C-reactive protein, Hb hemoglobin, IL-1RA interleukin-1 receptor antagonist, CXCL10 CXC motif ligand 10, sCD40L soluble CD40 ligand, N/A not available (median was below or over LOD)
  3. Definitions: low body mass index: < 20 kg/m2; low albumin: < 3.5 g/dL; high C-reactive protein: > 0.3 mg/dL; Anemia: Hb < 12.0 g/dL in males and < 11.0 g/dL in females
  4. *P-values were calculated using Wilcoxon rank sum test. If more than half of one group was lower LOD, we used Fisher’s exact test with cut-off as LOD value. NS, not significant