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Table 4 Occurrence of grade 3 symptoms, complications, and healthcare use associated with confirmed influenza episodes

From: Epidemiology and burden of influenza in healthy children aged 6 to 35 months: analysis of data from the placebo arm of a phase III efficacy trial

 

Confirmed influenza episodes

Proportion of episodes

Laboratory-confirmed influenza associated with:

N = 263

(%)

Grade 3 symptoms

 

 Grade 3 fever a

63

24.3

 ≥ 1 grade 3 influenza-like illness symptom b

8

3.0

Complications

 

 Acute otitis media

16

6.1

 Acute lower respiratory infection

23

8.7

 Pneumonia

5

1.9

Medication

 

 Any

257

97.7

Antibiotics

109

41.4

 Antipyretic or analgesic medication c

245

93.2

 Antitussives

8

3.0

 Bronchodilators

36

13.7

 Expectorants

10

3.8

 Mucolytic agents

47

17.9

Healthcare use

 

 Outpatient visit

150

57.0

 Inpatient hospitalisation

3

1.1

 Intensive care unit admission

0

0.0

  1. a> 39.5 °C for subjects aged < 24 months and ≥ 39.0 °C for subjects aged ≥24 months
  2. bCough, nasal congestion, rhinorrhoea, pharyngitis, otitis, vomiting, or diarrhoea preventing daily activities
  3. cIncludes non-steroidal anti-inflammatory drugs