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Table 3 Factors associated with disease progression of nontuberculous mycobacterial lung disease

From: Nontuberculous mycobacterial pulmonary disease diagnosed by two methods: a prospective cohort study

Variables

Unadjusted HR (95% CI)

Adjusted HR (95% CI)

Age, by each year

0.97 (0.96–0.99) *

0.97 (0.96–0.99) *

Sex, female

1.38 (0.96–2.00)

–

Body mass index, by 1 kg/m2

0.89 (0.83–0.95) *

0.94 (0.87–1.01)

Smoking

 Never smoker

Reference

–

 Former smoker

0.72 (0.47–1.18)

–

 Current smoker

1.82 (0.80–4.15)

–

Haemoglobin, by 1 g/dL

0.83 (0.73–0.95) *

0.89 (0.75–1.06)

Platelet, by 1000/μL

1.00 (1.00–1.01) *

1.00 (1.00–1.00)

Total protein, by 1 g/dL

1.88 (1.22–2.89) *

1.57 (0.97–2.52)

Total bilirubin, by 1 mg/dL

0.40 (0.18–0.85) *

0.42 (0.17–1.04)

SGRQ score, by each score

1.01 (1.00–1.02)

–

FEV1, by 1 L

1.00 (1.00–1.00)

–

FVC, by 1 L

1.00 (1.00–1.00)

–

DLCO, by 1%

0.99 (0.98–1.00) *

0.99 (0.98–1.01)

Computed tomography type

 Nodular bronchiectatic form

Reference

Reference

 Upper lobe cavitary form

3.69 (2.30–5.94) *

3.16 (1.78–5.62) *

Diagnostic method

 NTM culture on two sputum specimens

Reference

Reference

 NTM culture on bronchoscopic specimen

0.93 (0.59–1.48)

0.82 (0.48–1.38)

  1. * Indicates statistical significance with P-value< 0.05
  2. Abbreviations: SGRQ St. George’s Respiratory Questionnaire, FEV1 forced expiratory volume in 1 second, FVC forced vital capacity, DLCO diffusing capacity of the lungs for carbon monoxide