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Table 2 Characteristics of N = 341 children with acute respiratory tract infection due to RSV-A, stratified by settinga and RSV-A subtype (RSV-A ON1 vs. RSV-A non-ON1); Bavaria (Germany), 2010/11–2016/17

From: Spread and clinical severity of respiratory syncytial virus A genotype ON1 in Germany, 2011–2017

  Pediatric practice (PP) Pediatric ward (PW) Pediatric intensive care unit (PICU)
  ON1 non-ON1 p ON1 non-ON1 p ON1 non-ON1 p
  N = 60 (100) N = 12 (100) N = 138 (100) N = 27 (100) N = 49 (100) N = 55 (100)
Female sex 28 (46.7) 4 (33.3) 0.53 55 (39.9) 16 (59.3) 0.88 20 (40.8) 27 (49.1) 0.44
Age, years 2.5 (1.9; 3.7) 2.4 (1.9; 3.4) 0.75 1.1 (0.5; 2.3) 1.4 (0.6; 2.9) 0.50 0.3 (0.1; 1.5) 0.2 (0.1; 0.5) 0.02
Age, month 3.4 (1.7; 18.3) 1.8 (1.5; 6.4) 0.02
Premature birth 3 (5.0) 0 (0) 1.00 17 (12.3) 4 (14.8) 0.75 17 (34.7) 9 (16.4) 0.04
Other preexisting conditionb 6 (10.0) 2 (16.7) 0.61 52 (37.7) 6 (22.2) 0.19 13 (26.5) 10 (18.2) 0.35
Viral coinfectionc 29 (48.3) 7 (58.3) 0.75 46 (33.3) 12 (44.4) 0.28 22 (44.9) 16 (29.1) 0.11
Considered severe 1 (1.7) 1 (8.3) 0.31
Considered life threatening 7 (15.9) 10 (18.9) 0.79
Cough 48 (80.0) 9 (75.0) 0.71 107 (77.5) 27 (100) < 0.01 41 (83.7) 44 (80.0) 0.80
Rhinitis 47 (78.3) 10 (83.3) 1.00 83 (60.1) 21 (77.8) 0.13 36 (73.5) 32 (58.2) 0.14
Refusal to eat / drink 5 (8.3) 1 (8.3) 1.00 65 (47.1) 17 (63.0) 0.15 25 (51.0) 35 (63.6) 0.24
Tachypnea 53 (38.4) 10 (37.0) 1.00 44 (89.8) 43 (78.2) 0.12
Fever 59 (100) 12 (100) 68 (49.3) 12 (44.4) 0.68 17 (34.7) 16 (29.1) 0.67
Fever, °C 39.8 (39.0; 40.2) 39.3 (39.1; 40.3) 0.91 38.7 (38.2; 39.3) 39.2 (38.5; 39.8) 0.07 38.8 (38.3; 39.0) 39.0 (38.8; 39.4) 0.20
Bronchitis / Bronchiolitis 26 (43.3) 4 (33.3) 0.75 68 (49.3) 9 (33.3) 0.15 37 (75.5) 47 (85.5) 0.22
Pneumonia 5 (8.3) 0 (0) 0.58 36 (26.1) 11 (40.7) 0.16 35 (71.4) 37 (67.3) 0.68
Sec. bacterial pneumonia 1 (0.7) 0 (0) 1.00 15 (30.6) 11 (20.0) 0.26
Symptoms, days 11 (8.5; 14) 10.5 (7; 13.5) 0.91
Hospital stay, days 3.0 (2.0; 5.0) 4.0 (3.0; 6.0) 0.10 8.0 (6.5; 12.0) 7.0 (5.0; 9.0) 0.02
PICU stay, days 5.0 (3.0; 7.5) 4.0 (2.0; 7.3) 0.23
Oxygen 59 (42.8) 12 (44.4) 1.00 47 (95.9) 46 (83.6) 0.06
Oxygen, days 3.0 (1.8; 5.0) 2.0 (1.8; 5.3) 0.77 6.0 (4.0; 9.0) 4.0 (2.0; 6.0) 0.03
CPAP 20 (40.8) 16 (29.1) 0.22
CPAP, days 2.5 (2.0; 4.8) 2.5 (2.0; 5.5) 0.89
Mechanical ventilation 7 (14.3) 4 (7.3) 0.34
Mechanical ventilation, days 6.5 (2.5, 8.5) 6.0 (2.3; 12.0) 0.91
Well-being at discharge 137 (99.3) 27 (100) 1.00 48 (98.0) 53 (96.4) 1.00
Well-being 14 days past visit 53 (89.8) 11 (91.7) 1.00
  1. Data shown are number of cases (percent of N) or median (quartiles). P-values were derived using Fisher’s exact test or Mann-Whitney U-test, as appropriate. P-values in boldface indicate statistical significance
  2. aNote that data from PP, PW and PICU were collected during different seasons (PP: 2012/13–2014/15, PW: 2011/12–2016/17, PICU: 2010/11–2016/17), and in different age groups (PP 1–5 years, PW and PICU up to 16 years)
  3. bIncluding mainly chronic lung disease (11% of 341patients), chronic neurological disorders (9%), cardiac malformation (6%), and immunocompromising conditions (4%)
  4. cRefers to coinfection with a different respiratory virus detected in the initial multiplex PCR