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Table 3 Factors associated with MTB strains harboring inhA mutation in 2015

From: Change in prevalence and molecular characteristics of isoniazid-resistant tuberculosis over a 10-year period in China

Characteristics

No. of INH-resistant isolates (%)

P value

OR (95% CI)

With inhA mutation

(n = 28)

Without inhA mutation

(n = 77)

Sex

 Men

18(64.3)

51(66.2)

0.85

1.09(0.44–2.70)

 Women

10(35.7)

26(33.8)

 

1.00(Ref)

Age group (years)

 <25

3(10.7)

6(7.8)

0.39

0.47(0.10–2.30)

 25–44

8(28.6)

34(44.2)

 

1.00(Ref)

 45–64

12(42.9)

27(35.1)

0.22

0.53(0.19–1.48)

 >64

5(17.9)

10(13.0)

0.29

0.47(0.13–1.76)

Treatment History

 New case

16(35.7)

47(79.2)

 

1.00(Ref)

 Re-treated

12(64.3)

30(20.8)

0.72

0.85(0.35–2.05)

Previous drug exposure

 INH

12(77.8)

30(26.0)

0.72

0.85(0.35–2.05)

 RIF

12(77.8)

30(26.0)

0.72

0.85(0.35–2.05)

 EMB

12(77.8)

30(26.0)

0.72

0.85(0.35–2.05)

 PZA

12(77.8)

30(26.0)

0.72

0.85(0.35–2.05)

 SLID

8(32.1)

19(15.6)

0.69

0.82(0.31–2.16)

 FQ

10(39.3)

22(20.8)

0.48

0.72(0.29–1.80)

 PTH

6(21.4)

4(5.2)

0.02

0.20(0.05–0.78)