Table 2 Comparison of published meta-analyses of Xpert® MTB/RIF for diagnosis of extrapulmonary tuberculosis
Author/Year | Search period | Groups of children included | Number of studies included in the meta-analysis | Number of specimens included | Specimen types | Accuracy of Xpert | ||||
|---|---|---|---|---|---|---|---|---|---|---|
All samples | Lymph node TB | TB meningitis | Pleural TB | Bone or joint TB | ||||||
Chang, 2012 | Up to Oct 1, 2011 | No classification by age | 7 | 1058 | Multiple forms combined | Sensitivity 80.4%; Specificity 86.1% | Not reported | Not reported | Not reported | Not reported |
Denkinger, 2014 | Up to Oct 15, 2013 | 10 studies included children | 18 | 4461 | Lymph node, CSF, Pleural fluid | Sensitivity 97.4%; Specificity not reported | Sensitivity 83%; Specificity 94% | Sensitivity 81%; Specificity 98% | Sensitivity 46%; Specificity 99% | Not reported |
Maynard-Smith, 2014 | Up to Nov 6, 2013 | 3 studies enrolled only children, 3 included all age-groups | 27 | 6026 | Lymph node, CSF, Other forms | Median sensitivity 83% (IQR, 68–94%; median specificity 98% (IQR, 89–94%) | Sensitivity 96%; Specificity 93% | Median sensitivity 85% (IQR, 75–100%); Median specificity 100% (IQR, 98–100%) | Sensitivity 34%; Specificity 98% | Not reported |
Penz, 2015 | Up to Aug 15, 2014 | No classification by age | 36 | 9523 | Lymph node, CSF, Other forms | Sensitivity 77%; Specificity 97% | Sensitivity 87%; Specificity 92% | Sensitivity 69%; Specificity 97% | Sensitivity 37%; Specificity 98% | Not reported |
Sehgal, 2016 | Up to Aug 31, 2015 | No classification by age | 24 | 2486 | Pleural fluid | Pleural fluid samples only | Not reported | Not reported | Sensitivity 51.4%; Specificity 98.6% | Not reported |
Li S, 2017 | Up to June 20, 2015 | No classification by age | 26 | Not reported | Multiple forms combined | Sensitivity 80%; Specificity 97% | Not reported | Not reported | Not reported | Not reported |
Kohli, 2018 | Up to Aug 7, 2017 | 30 studies included children | 66 | 16213 | Lymph node, CSF, Other forms | Varied across different types of specimens | Sensitivity 87.6%; Specificity 86.0% | Sensitivity 71.1%; Specificity 98.0% | Sensitivity 50.9%; Specificity 99.2% | Sensitivity 97.2% (fluid), 91.8%(tissue); Specificity 90.2% (fluid), 82.0% (tissue) |
Yu G, 2019 | Up to Jul 6, 2018 | No classification by age | 21 | 1629 | Lymph node | Lymph node samples only | Sensitivity 84%; Specificity 91% | Not reported | Not reported | Not reported |
Shen Y, 2019 | Up to May 7, 2019 | No classification by age | 14 | 1884 | Bone or joint samples | Bone and joint samples only | Not reported | Not reported | Not reported | Sensitivity 82% (pus), 84% (tissue); Specificity 99% (pus), 98% (tissue) |
Current study | Up to Jul 16, 2019 | Only samples taken from children were included | 8 | 597 | Lymph node, CSF, Other forms | Sensitivity 71.3%; Specificity 97.2% | Sensitivity 80.2%; Specificity 94.0% | Sensitivity 41.7%; Specificity 98.7% | Meta-analysis could not be performed | Meta-analysis could not be performed |