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Table 4 C-reactive protein (CRP) and procalcitonin (PCT) values in patients of acute Q fever with and without delayed responses to doxycycline treatmenta

From: Serum C-reactive protein and procalcitonin values in acute Q fever, scrub typhus, and murine typhus

 

Treatment to defervescence ≤3 days

Treatment to defervescence > 3 days

p

CRP (mg/L)

 Acute phase (Mean ± SD)

 

79.1 ± 61.2

107.8 ± 68.8

0.096

> 25

77.6% (52/67)

94.1% (16/17)

0.174

> 50

67.2% (45/67)

82.4% (14/17)

0.373

> 75

44.8% (30/67)

58.8% (10/17)

0.300

> 100

34.3% (23/67)

47.1% (8/17)

0.331

> 150

10.4% (7/67)

17.6% (3/17)

0.415

> 200

3.0% (2/67)

11.8% (2/17)

0.181

 Convalescent phase (Mean ± SD) b

 

5.3 ± 17.4

20.7 ± 45.2

0.103

> 25

3.1% (1/32)

7.7% (1/13)

0.499

> 50

3.1% (1/32)

7.7% (1/13)

0.499

> 75

3.1% (1/32)

7.7% (1/13)

0.499

> 100

0% (0/46)

7.1% (1/14)

0.289

PCT (ng/mL)

 Acute phase (Mean ± SD)

 

1.07 ± 1.45

1.67 ± 1.78

0.187

> 0.25

75.4% (46/61)

85.7% (12/14)

0.502

> 0.5

49.2% (30/61)

78.6% (11/14)

0.073

> 1.0

29.5% (18/61)

57.1% (8/14)

0.050*

> 1.5

23.0% (14/61)

28.6% (4/14)

0.731

> 2.0

13.1% (8/61)

21.4% (3/14)

0.420

> 4.0

6.6% (4/61)

14.3% (2/14)

0.311

 Convalescent phase (Mean ± SD)b

 

0.06 ± 0.10

0.17 ± 0.20

0.098

> 0.25

7.1% (3/42)

33.3% (4/12)

0.036*

> 0.5

0% (0/42)

8.3% (1/12)

0.222

> 1.0

0% (0/42)

0% (0/12)

NC

  1. SD standard deviation, NC not calculated
  2. *p < 0.05 indicates statistical significance
  3. aPatients who received fluoroquinolones or achieved defervescence before intervention of doxycycline treatment were excluded
  4. bTests for the convalescent phase of acute Q fever were performed 12–45 days from the disease onset (average, 20.3 ± 6.1 days; median, 18.5 days)