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Table 5 Bi-variable and multi-variable Weibull regression analysis for predictors of virological failure among adult HIV patients on first-line ART in Amhara regional referral hospitals; Ethiopia from September 2015 to December 2018(N = 490)

From: Incidence and predictors of virological failure among adult HIV patients on first-line antiretroviral therapy in Amhara regional referral hospitals; Ethiopia: a retrospective follow-up study

Variables categories Status CHR(95%CI) AHR(95%CI)
   Event Censored   
Age in year 15–24 13 65 2.02 (0.77–5.33) 0.67 (0.19–2.35)
25–34 27 169 1.68 (0.69–4.07) 1.24 (0.47–3.23)
35–44 15 127 1.36 (0.52–.3.50) 0.80 (0.29–2.21)
> = 45 6 68 1 1
Sex Male 30 173 1.48 (0.90–2.46) 1.46 (0.83–2.57)
Female 31 256 1 1
Educational status No education 15 113 1 1
Primary 22 100 1.62 (0.84–3.12) 1.32 (0.64–2.71)
Secondary above 24 216 0.81 (0.42–1.56) 0.71 (0.33–1.49)
Occupation Un employed 19 85 2.21 (1.23–3.97) 1.52 (0.73–3.15)
Employed 9 81 1.06 (0.50–2.25) 1.88 (0.80–4.42)
Daily laborer 5 19 2.54 (0.99–6.58) 1.35 (0.49–3.75)
Self-employed 28 244 1 1
CPT Yes 32 239 1 1
No 29 190 1.40 (0.84–2.32) 1.8 (1.03–3.16)*
Baseline functional status Working 40 345 1 1
Ambulator/bedridden 21 84 1.98 (1.16–3.36) 1.23 (0.65–2.32)
Adherence Good 32 382 1 1
Fair/poor 29 47 6.16 (3.7–10) 5.46 (3.06–9.74)*
TB/HIV-co-infection Yes 15 77 1.91 (1.07–3.43) 1.27 (0.65–2.51)
No 46 352 1 1
First-line drug regimen EFV based 42 395 1 1
NVP based 19 34 3.82 (2.22–6.5) 3.53 (1.73–7.21)*
Hemoglobin level Anemic 25 81 2.6 (1.57–4.35) 1.46 (0.83–2.57)
Not anemic 36 348 1 1
Baseline CD4 count <=200 29 163 2.83 (0.86–9.3) 3.9 (1.07–13.9)*
201–350 18 110 2.47 (0.72–8.41) 4.1 (1.12–15)*
351–500 11 90 1.96 (0.54–7.04) 2.14 (0.54–8.5)
> 500 3 66 1 1
Baseline WHO stage Stage I/II 29 275 1 1
Stage III/IV 32 154 1.80 (1.1–2.98) 1.15 (0.61–2.20)
Past OI Yes 23 127 1.42 (0.85–2.39) 1.21 (0.61–2.41)
No 38 302 1 1
  1. *-p-value < 0.05 statistically significant