Table 4 The antibiotic regimens, complications and outcomes between the groups
Antibiotics (n = 52) | PNA(n = 42) | P value | |
|---|---|---|---|
Duration of IV antibiotics (days) | 15.9 ± 8.4 | 15.1 ± 6.8 | 0.611 |
ESBL positive, n(%) | 1(20.0%) | 9 (28.1%) | 0.704 |
Carbapenems, n (%) | 21(40.4%) | 6(14.3%) | 0.005 |
Antibiotics use density | 211.7 ± 97.5 | 238.5 ± 90.5 | 0.174 |
Complications, n (%) | |||
Sepsis | 17(32.7%) | 15(35.7%) | 0.759 |
Elevated serum transaminase | 5(9.6%) | 3(7.1%) | 0.669 |
Elevated Troponin | 1(1.9%) | 2(4.8%) | 0.436 |
Thrombocytopenia | 12(23.1%) | 9(21.4%) | 0.849 |
Pleural effusion | 0 | 3(7.1%) | 0.050 |
Enteric infection | 0 | 1(2.4%) | 0.263 |
Endophthalmitis | 1(1.9%) | 0 | 0.366 |
Aspiration related complications, n (%) | NS | 0 | NS |
Outcomes | |||
Time for temperature normalization (days) | 4.3 ± 2.6 | 2.7 ± 1.5 | < 0.001 |
Reduction rate of CRP within first week (mg/L·day) | 15.4 ± 8.5 | 21.2 ± 12.0 | 0.031 |
Hospital stay (days) | 16.1 ± 8.4 | 15.3 ± 6.8 | 0.626 |
Readmission within 60 days, n (%) | 3(5.8%) | 0 | 0.114 |
Mortality, n (%) | 1(1.9%) | 0 | 0.263 |