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Table 6 Penicillin and tetracycline antimicrobial susceptibility data and identified AMR determinants

From: Plasmid mediated penicillin and tetracycline resistance among Neisseria gonorrhoeae isolates from Kenya

  Tetracyclines   Penicillin G  
MIC (mg/L) tetM Plasmid S10 MIC (mg/L) β-lactamase penA allele PonA MtrR PenB
  Sample ID DOX TET PEN
1 KNY_NGAMR1 0.75 0.064 Absent V57M 0.064 NP Pattern XIV A121G, G120D, −N122
2 KNY_NGAMR2 1.5 0.5 Absent V57M 64 TEM1a Pattern II L421P G45D, −A13 G120D
3 KNY_NGAMR3 6 16 Present V57M 48 TEM239 Pattern IX L421P A39T
4 KNY_NGAMR4 16 12 Present V57M 8 TEM1 Pattern XIX A39T A121S, N122K
5 KNY_NGAMR5 12 16 Present V57M 3 TEM1 Pattern IX L421P H105Y A121G, G120N, −N122
6 KNY_NGAMR6 0.75 0.75 Absent V57M 0.094 NP Pattern II A39T
7 KNY_NGAMR7 12 16 Present V57M > 256 TEM239 Pattern XXII L421P A121S, N122K
8 KNY_NGAMR8 0.5 0.5 Absent V57M 0.064 NP Pattern XIV L421P A39T A121G, G120D, −N122
9 KNY_NGAMR10 24 32 Present V57M > 256 TEM1 Pattern II A39T
10 KNY_NGAMR11 12 12 Present V57M 12 TEM1 Pattern XIV L421P A39T A121G, G120D, −N122
11 KNY_NGAMR13 12 12 Present V57M 8 TEM1 Pattern XIV L421P A39T A121G, G120D, −N122
12 KNY_NGAMR14 8 24 Present V57M 64 TEM1 Pattern II A39T A121S, N122K
13 KNY_NGAMR15 16 32 Present V57M 48 TEM1 Pattern XIV L421P A39T A121G, −N122
14 KNY_NGAMR16 8 4 Present V57M 0.19 NP Pattern XIV A39T A121G, −N122
15 KNY_NGAMR17 12 16 Present V57M 0.38 NP Pattern XXII L421P T86A, D79N, H105Y
16 KNY_NGAMR18 32 24 Present V57M 0.5 TEM1 Pattern XIX A39T
17 KNY_NGAMR19 96 64 Presentb V57M 0.19 NP Pattern XIV L421P A39T
18 KNY_NGAMR20 16 24 Present V57M 12 TEM1 Pattern IX L421P A39T A121G, G120D, −N122
19 KNY_NGAMR21 16 24 Present V57M 32 TEM1 Pattern XIV L421P A39T A121G, G120D, −N122
20 KNY_NGAMR22 12 32 Present V57M 2 TEM1 Pattern XIX A39T
21 KNY_NGAMR23 16 8 Present V57M 12 TEM1 Pattern IX L421P A39T A121G, G120D, −N122
22 KNY_NGAMR24 16 16 Present V57M 2 TEM1 Pattern XIX A39T
23 KNY_NGAMR26 24 32 Present V57M 8 TEM239 Pattern XIV A39T A121G, −N122
24 KNY_NGAMR27 16 32 Present V57M 1 TEM239 Pattern XIV A39T
25 KNY_NGAMR28 24 32 Present V57M 96 TEM1 Pattern II A39T A121G, −N122
26 KNY_NGAMR29 4 12 Present V57M 0.094 NP Pattern XIV L421P A39T A121G, −N122
27 KNY_NGAMR30 12 12 Present V57M 12 TEM1 pattern XIV L421P A39T A121G, −N122
28 KNY_NGAMR31 24 48 Present V57M 0.38 NP Pattern II A39T A121G, G120D, −N122
29 KNY_NGAMR32 1 0.5 Absent V57M 8 TEM1 Pattern XIV L421P A39T A121G, G120D, −N122
30 KNY_NGAMR33 24 32 Present V57M 3 NP Pattern XIV A39T A121G, −N122
31 KNY_NGAMR35 24 48 Present V57M > 256 TEM1 Pattern II A39T
32 KNY_NGAMR41 12 12 Present V57M 32 TEM1 Pattern XIX A39T
33 KNY_NGAMR42 12 24 Present V57M 32 TEM1 Pattern XIV T86A, D79N, H105Y
34 KNY_NGAMR50 32 16 Present V57M 16 TEM1 Pattern II A39T A121G, G120D, −N122
35 KNY_NGAMR53 16 6 Present V57M 6 TEM239 Pattern XIV L421P A39T A121G, −N122
36 KNY_NGAMR54 8 2 Present V57M 6 NP Pattern XXII A39T
  1. DOX Doxycycline, TET Tetracycline, PEN Penicillin (a)β-lactamase encoding plasmid with an Asian plasmid backbone, (b)Dutch TetM determinant, NP Not present, “-” no mutation identified, (−N122)- deletion of N at position 122 of PenB, (−A13)- Adenine deletion in the 13 bp inverted repeat region between the − 10 and − 35 hexamers of the mtrR promoter
  2. Pattern XXII; D346, F505L, A511V, A517G H542N, P553V, K556Q, I557V, I567V, N575, A576V
  3. Pattern IX; D346, F505L, A511V, A517G, P552L
  4. Pattern XIX; D346, F505L, A511V, A517G, H542N, I567V, N575, A576V
  5. Pattern XIV; D346, F505L, A511V, A517G, H542N
  6. Pattern II; D346, F505L, A511V, A517G