Table 3 Major clinical manifestations of nervous system damage caused by EBV
From: Clinical characteristics of Epstein–Barr virus infection in the pediatric nervous system
Symptoms (Number of cases) | Encephalitis/meningoencephalitis (n = 64) | Myelitis (n = 2) | EBV-HLH (n = 4) | NS-PTLD (n = 1) | ADEM (n = 3) | GBS (n = 15) |
|---|---|---|---|---|---|---|
Fever | 60 | 2 | 4 | 1 | 3 | 4 |
Intracranial hypertension | 37 | 0 | 1 | 0 | 1 | 2 |
Drowsy-lethargy | 7 | 0 | 1 | 0 | 1 | 2 |
Coma | 15 | 0 | 0 | 0 | 2 | 0 |
Convulsions (not including SE) | 21 | 0 | 0 | 0 | 0 | 0 |
Status epilepticus | 8 | 0 | 0 | 1 | 2 | 0 |
Mental symptoms | 4 | 0 | 0 | 0 | 0 | 0 |
Central respiratory failure | 8 | 0 | 1 | 0 | 1 | 0 |
Peripheral respiratory failure | 1 | 1 | 0 | 0 | 0 | 3 |
Ataxia | 3 | 0 | 0 | 1 | 1 | 0 |
Facial nerve | 5 | 0 | 0 | 0 | 2 | 1 |
Oculomotor nerve | 0 | 0 | 0 | 0 | 1 | 2 |
Bulbar paralysis | 0 | 0 | 0 | 0 | 0 | 10 |
Pyramidal tract sign | 24 | 2 | 0 | 0 | 1 | 0 |
Meningeal irritation sign | 24 | 1 | 0 | 0 | 3 | 9 |
Increased muscle tension | 13 | 1 | 0 | 0 | 2 | 0 |
Decreased muscle tension | 7 | 2 | 0 | 0 | 2 | 9 |
Decreased muscle strength | 9 | 2 | 0 | 0 | 2 | 15 |
Defecation disorder | 0 | 1 | 0 | 0 | 0 | 3 |
Urination disorder | 1 | 0 | 0 | 0 | 1 | 4 |
Nerve root pain | 0 | 1 | 0 | 0 | 0 | 2 |