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Table 3 Relative risk (RR) estimates and 95% credible intervals (95% CrI) for the association between IC condition and HZ incidence, HZ-complications and HZ recurrence, controlling by sex, age, comorbidities (COPD, diabetes, HF and CKD), health department (as a random effect) and calendar year, using Bayesian Poisson regression

From: Herpes zoster risk and burden of disease in immunocompromised populations: a population-based study using health system integrated databases, 2009–2014

 

aHZ RR (95% CrI)

bHZ-Complications

RR (95% CrI)

bHZ-Recurrence

RR (95% CrI)

IC

IC-free

1

1

1

IC

1.51 (1.48–1.54)

2.37 (2.01–2.8)

1.25 (1.19–1.31)

SEX

Man

1

1

1

Woman

1.33 (1.31–1.35)

1.15 (0.98–1.35)

1.19 (1.14–1.24)

AGE

18–29

1

1

1

30–39

1.06 (1.02–1.09)

5.62 (2.63–11.99)

1.08 (0.95–1.23)

40–49

1.24 (1.2–1.29)

9.71 (4.9–19.24)

1.14 (1.01–1.28)

50–59

2.42 (2.35–2.5)

7.74 (3.95–15.16)

1.21 (1.08–1.36)

60–69

3.43 (3.32–3.54)

12.3 (6.84–22.1)

1.52 (1.36–1.7)

70–79

3.72 (3.61–3.85)

26.14 (14.72–46.44)

1.9 (1.7–2.12)

≥ 80

3.57 (3.45–3.7)

39.72 (22.5–70.12)

2.14 (1.91–2.4)

COMORBIDITIES

COPD

NO-COPD

1

1

1

COPD

1.36 (1.32–1.4)

2.54 (2.11–3.06)

1.26 (1.17–1.35)

DIABETES

NO-DIABETES

1

1

1

DIABETES

1.12 (1.09–1.14)

1.07 (0.89–1.28)

1.05 (1–1.11)

HF

NO-HF

1

1

1

HF

1.16 (1.11–1.21)

2.07 (1.68–2.55)

1.63 (1.39–1.9)

CKD

NO-CKD

1

1

1

CKD

1.18 (1.13–1.23)

1.63 (1.31–2.03)

1.2 (1.09–1.33)

  1. aA Quasi poisson regression model adjusted by sex, age, calendar year, health department and comorbidities (COPD, diabetes, HF and CKD) was used to estimate the risk of HZ in IC respect to IC-free subjects
  2. bA Zero-inflated negative binomial model adjusted by sex, age, calendar year, health department and comorbidities (COPD, diabetes, HF and CKD) was used to estimate the risk of HZ complications (based on hospitalization diagnoses) and recurrence in IC respect to IC-free