Fig. 3

Volcano plot for genes that change over time in the entire patient cohort (a), or that have differential expression pre- (b) or post-treatment (c) based on treatment response. For A, genes in green with a negative log fold change had decreased expression during treatment, while genes in red with a positive fold change had increased expression. For B-C, genes with a negative fold change (in green) had lower expression in relapsers compared to patients achieving SVR, while genes with a positive fold change (in red) had higher expression in relapsers. Genes with labels have a p-value < 0.05 and a fold change of 1.5 or greater