Table 3 Clinical characteristics of psychiatric patients stratified by achieving SVR-12
SVR-12 (N = 127) | No SVR-12 (N = 17) | p-value | |
|---|---|---|---|
Sex, males.n(%) | 58 (45.7%) | 13 (76.5%) | 0.020 |
Age, years, mean (SD) | 61.8 ± 13.3 | 51.6 ± 11.7 | 0.038 |
Risk Factorsn(%) | |||
IDU | 28 (22.0%) | 9 (52.9%) | 0.014 |
Heterosexual | 10 (7.9%) | 0 | 0.607 |
MSM | 1 (0.8%) | 0 | 1.000 |
Nosocomial | 36 (28.3%) | 2 (11.8%) | 0.239 |
Unknown | 52 (41.0%) | 6 (35.3%) | 0.794 |
HCV Genotypesn(%) | |||
1a | 27 (21.3%) | 5 (29.4%) | 0.534 |
1b | 45 (35.4%) | 6 (35.3%) | 1.000 |
2 | 35 (27.6%) | 2 (11.8%) | 0.238 |
3 | 15 (11.8%) | 3 (17.6%) | 0.448 |
4 | 5 (3.9%) | 1 (5.9%) | 0.536 |
Log 10 HCV-RNA, IU/mL, median (range) | 6.00 (5.5–6.5) | 6.1 (5.5–6.7) | 0.841 |
Liver stiffness, Kpa, mean (SD) | 11.1 ± 10.4 | 8.9 ± 3.4 | |
Previous failure,n(%) | 24 (18.9%) | 8 (47.0%) | 0.024 |
INF-based tx | 23 | 8 | |
DAAs-based tx | 1 | 0 | |
FIB-4 score median (range) | 2.0 (1.4–3.3) | 1.5 (1.3–2.1) | 0.226 |
APRI score median (range) | 0.6 (0.4–1.2) | 0.6 (0.5–1.2) | 0.936 |
MELD score median (range) | 7.0 (6.0–8.0) | 7.0 (6.0–7.0) | 0.794 |
Cirrhosis,n(%) | 40 (31.5%) | 6 (35.3%) | 0.785 |
Oesophageal varices or portal hypertension,n(%) | 13 (10.2%) | 2 (11.8%) | 0.691 |
Type of HCV therapyn(%) | |||
SOF + RBV | 7 (5.5%) | 0 | 0.594 |
SOF + SMV ± RBV | 5 (3.9%) | 0 | 1.000 |
SOF + LDV ± RBV | 18 (14.2%) | 3 (17.6%) | 0.715 |
SOF + DCV ± RBV | 11 (8.7%) | 2 (11.8%) | 0.652 |
OMB + PTV/r + DAS ± RBV | 13 (10.2%) | 2 (11.8%) | 0.691 |
OMB + PTV/r + RBV | 1 (0.8%) | 1 (5.9%) | 0.222 |
SOF + VEL ± RBV | 30 (23.6%) | 7 (41.2%) | 0.141 |
GLE + PIB | 24 (18.9%) | 0 | 0.076 |
GRZ + EBR ± RBV | 18 (14.2%) | 2 (11.8%) | 1.000 |
Addition of RBVn(%) | 27 (21.2%) | 6 (35.3%) | 0.222 |
ALT, UI/L, median (range) | 50 (28.5–77.5) | 70 (47–125) | 0.031 |
Total bilirubin, mg/dL, median (range) | 0.62 (0.44–0.83) | 0.60 (0.40–0.80) | 0.561 |
Serum creatinine, mg/dL, median (range) | 0.79 (0.61–0.95) | 0.78 (0.63–0.80) | 0.928 |
Platelets (×10^9/L), median (range) | 182 (139–219) | 185 (157–210) | 0.920 |
Patients with at least 1 other comorbidity, n (%) | 94 (74%) | 7 (41.2%) | 0.009 |
Diabetes,n(%) | 18 (14.2%) | 2 (11.8%) | 1.000 |
Hypertension,n(%) | 57 (44.9%) | 4 (23.5%) | 0.119 |
HIV infected,n(%) | 17 (13.4%) | 2 (11.8%) | 1.000 |