Polymorphism rs368234815 of interferon lambda 4 gene and spontaneous clearance of hepatitis C virus in haemodialysis patients: a case-control study

Table 1 Demographic, clinical, and laboratory data of 161 HD patients showing positive anti-HCV antibodies

Parameter	HCV RNA positive n = 93	HCV RNA negative n = 68	P value^†
Male gender	48 (51.6)	35 (51.5)	0.986
Age at RRT onset, years	45.8 (8.7–79.5)	53.5 (14.1–85.9)	0.004
Diabetic nephropathy	17 (18.3)	17 (25.0)	0.302
Chronic glomerulonephritis	31 (33.3)	11 (16.2)	0.014
Hypertensive nephropathy	10 (10.8)	9 (13.2)	0.630
RRT duration, years	13.4 (0–32.0)	7.0 (0.2–33.2)	0.0009
BMI, kg/m²	23.1 (15.2–50.4)	23.5 (16.2–37.1)	0.471
HBsAg positivity	5 (5.4)	5 (7.4)	0.744^‡
Anti-HBc positivity	48 (51.6)	32 (47.1)	0.568
Not generating anti-HBs	16 (17.2)	17 (25.0)	0.226
Anti-HBs titre, IU/L	199.5 (0–8045)	284.0 (0–1100)	0.889
ALT, IU/L	24 (2–195)	12.4 (3–63)	0.00007
AST, IU/L	23 (8–152)	15 (8–46)	0.00001
ALP, IU/L	110 (15–647.3)	87.8 (45–803.8)	0.016
GGT, IU/L	48.5 (7–498)	27 (7–692)	0.001
C-reactive protein, mg/L	6.0 (0.2–127)	5.4 (0.3–101)	0.916
Albumin, g/dL	3.8 (1.9–4.7)	4.0 (2–4.9)	0.074

Results are presented as median and range (minimum-maximum) or the number of patients presenting the indicated parameter with the % of the total of tested patients shown in parentheses
Abbreviations: ALP alkaline phosphatase, ALT alanine aminotransferase, AST aspartate aminotransferase, Anti-HBc antibodies against core antigen of hepatitis B virus, Anti-HCV antibodies against hepatitis C virus, BMI body mass index, GGT gamma-glutamyltransferase, HBsAg surface antigen of hepatitis B virus, HCV RNA ribonucleic acid of hepatitis C virus, HD haemodialysis, RRT renal replacement therapy
Conversion factors to SI units are as follows: for alanine aminotransferase – 1 IU/L = 0.0167 μkat/L, for albumin – 1 g/dL = 10 g/L, for alkaline phosphatase – 1 IU/L = 0.0167 μkat/L, for aspartate aminotransferase – 1 IU/L = 0.0167 μkat/L, for C-reactive protein – 1 mg/L = 9.524 nmol/L, for gamma-glutamyltransferase – 1 IU/L = 0.0167 μkat/L
† Chi-squared test for qualitative variables and Mann-Whitney test for quantitative variables
^‡Fisher’s exact test

ISSN: 1471-2334