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Table 4 Univariable and multivariable analyses of the association between clinical and laboratory variables and death

From: Risk factors for mortality in patients over 70 years old with COVID-19 in Wuhan at the early break: retrospective case series

  Total n for analysis Univariable Analysis
HR (95%CI)
P Multivariable Analysis
HR (95%CI)
P*
Age 147 1.079 (1.027–1.134) 0.003   
Type 147     
Severe 42 2.896 (1.473–5.692) 0.002 2.983 (1.231–7.226) 0.016
Critical 16 3.542 (1.515–8.284) 0.004 3.267 (1.009–10.576) 0.048
Leukocytes (109/L) 147     
< 3.5 13 3.153 (1.251–7.948) 0.015   
> 9.5 32 3.931 (2.043–7.563) <  0.001   
Lymphocytes (109/L) 147     
< 1.1 100 2.656 (1.179–5.983) 0.018   
Neutrophils (109/L) 147     
< 1.8 9 1.289 (0.296–5.611) 0.735   
> 6.3 48 3.366 (1.786–6.344) 0.001   
AST (U/L) 147     
< 15 4 1.180 (0.158–8.831) 0.872   
> 40 50 2.523 (1.365–4.664) 0.003   
CK (U/L) 147     
< 50 50 0.814 (0.395–1.680) 0.578   
> 310 15 2.990 (1.373–6.511) 0.006   
Creatinine (μmol/L) 147     
< 57 37 1.527 (0.715–3.261) 0.274   
> 111 23 3.987 (1.961–8.103) 0.001   
BUN (mmol/L) 147     
< 3.6 7 1.623 (0.378–6.969) 0.515 3.812 (0.788–18.435) 0.096
> 9.5 37 3.913 (2.099–7.291) <  0.001 2.805 (1.141–6.892) 0.025
Globulin (g/L) 147     
< 20 12 0.263 (0.036–1.915) 0.187   
> 40 3 2.042 (0.493–8.468) 0.325   
Dyspnea 147 1.641 (0.895–3.007) 0.109   
Hormone therapy 147 2.393 (1.260–4.547) 0.008   
Antiviral therapy 147 0.188 (0.057–0.615) 0.006   
Oxygen therapy 147 4.154 (0.571–30.210) 0.160   
Vasoactive drugs 147 14.126 (7.238–27.569) < 0.001 16.120 (6.573–39.533) < 0.001
LDH (U/L) 147     
> 250 98 5.221 (1.862–14.639) 0.002   
Procalcitonin (ng/mL) 137     
> 0.1 64 2.715 (1.405–5.244) 0.003   
CD3 (/μL) 122     
< 723 93 9.718 (1.325–71.263) 0.025   
CD4 (/μL) 122     
< 404 95 6.496 (1.550–27.232) 0.011   
CD8 (/μL) 122     
< 220 85 3.089 (1.081–8.829) 0.035   
CD19 (/μL) 122     
< 80 43 1.975 (0.976–3.995) 0.058   
CD16 + CD56 (/μL) 122     
< 84 49 2.516 (1.221–5.186) 0.012   
IgA (g/L) 121     
> 4.0 19 1.012 (0.388–2.635) 0.981   
IgM (g/L) 121     
< 0.4 14 0.946 (0.286–3.126) 0.927   
> 2.3 3 2.416 (0.573–10.184) 0.230   
IgE (IU/mL) 121     
> 100 30 1.541 (0.725–3.272) 0.261   
  1. *A forward and backward stepwise selection with P values of 0.10 for the forward procedure and 0.05 for the backward procedure was used to select the variables for the final model. AST, aspartate aminotransferase; CK, creatine kinase; LDH, lactate dehydrogenase; BUN, blood urea nitrogen; IgM, immunoglobulin M; IgA, immunoglobulin A; IgE, immunoglobulin E; CD, cluster of differentiation. *P < 0.05