Table. 1 HScore for reactive hemophagocytic syndrome
From: Hemophagocytic syndrome secondary to SARS-Cov-2 infection: a case report
Variable | Points | Patient’s score | |
|---|---|---|---|
Known underlying immunosuppression HIV positive or receiving long‐term immunosuppressive therapy (i.e., glucocorticoids, cyclosporine, azathioprine) | No | 0 | No |
Yes | + 18 | ||
Temperature, °F (°C) | < 101.1 (< 38.4) | 0 | |
101.1–102.9 (38.4–39.4) | + 33 | ||
> 102.9 (> 39.4) | + 49 | 39.5 °C | |
Organomegaly | No | 0 | |
Hepatomegaly or splenomegaly | + 23 | Splenomegaly | |
Hepatomegaly and splenomegaly | + 38 | ||
Number of cytopenias Defined as hemoglobin ≤ 9.2 g/dL (≤ 5.71 mmol/L) and/or WBC ≤ 5000/mm3 and/or platelets ≤ 110,000/mm3 | 1 lineage | 0 | |
2 lineages | + 24 | ||
3 lineages | + 34 | Hb 7.7 g/dL, WBC 3700/mm3, platelets 27,000/mm3 | |
Ferritin, ng/mL (or μg/L) | < 2,000 | 0 | |
2000–6000 | + 35 | ||
> 6000 | + 50 | 20,696 ng/mL | |
Triglyceride, mg/dL (mmol/L) | < 132.7 (< 1.5) | 0 | |
132.7–354 (1.5–4) | + 44 | ||
> 354 (> 4) | + 64 | 428 mg/dL | |
Fibrinogen, mg/dL (g/L) | > 250 (> 2.5) | 0 | |
≤ 250 (≤ 2.5) | + 30 | 74 mg/dL | |
AST (aspartate aminotransferase), U/L | < 30 | 0 | |
≥ 30 | + 19 | 59 U/L | |
Hemophagocytosis features on bone marrow aspirate | No | 0 | No |
Yes | + 35 | ||
Total | 269 points (> 99% probability of hemophagocytic syndrome) | ||