Clinical characteristics and outcomes of neonates with polymicrobial ventilator-associated pneumonia in the intensive care unit

Table 4 Multivariate logistic regression analysis for independent risk factors of clinical treatment failure in neonatal ventilator-associated pneumonia

Variables	Univariate analysis		Multivariate analysis
Variables	OR (95% CI)	P values	Adjusted OR (95% CI)	P values
Gestational age
< 26 weeks	1.24 (0.37–4.17)	0.725
26–28 weeks	1.35 (0.42–4.36)	0.617
29–33 weeks	1 (reference)
≥ 34 weeks	1.93 (0.42–8.84)	0.395
Septic shock	4.67 (2.11–10.33)	< 0.001	3.14 (1.22–8.13)	0.018
On HFOV vs. conventional ventilator	4.45 (2.09–9.47)	< 0.001	3.90 (1.61–9.48)	0.003
Inappropriate initial antibiotics	0.74 (0.31–1.80)	0.513
Polymicrobial VAP	0.67 (0.28–1.62)	0.373
MDR pathogens associated VAP	1.05 (0.51–2.16)	0.896
Presences of neurological sequelae	2.53 (1.22–5.23)	0.012	2.74 (1.18–6.36)	0.019
Bronchopulmonary dysplasia	0.75 (0.35–1.57)	0.440
Severity of illness at onset of VAP
Every 3 increase in NTISS scores	3.01 (1.44–6.30)	0.003	2.16 (0.93–5.00)	0.074
Concurrent sepsis	5.73 (2.64–12.38)	< 0.001	6.34 (2.57–15.65)	< 0.001
Thrombocytopenia	3.00 (1.24–7.27)	0.015	1.50 (0.52–4.34)	0.452

HFOV high frequency oscillatory ventilator, OR odds ratio, 95% CI 95% confidence interval, MDR multidrug resistant, NTISS Neonatal Therapeutic Intervention Scoring System

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