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Table 4 Predictive efficacy of independent risk factors and constructed risk models for in-hospital mortality in all patients and ICU patients

From: Serum mAST/ALT ratio had high predictive value for adverse outcome of severe fever with thrombocytopenia syndrome with severe condition

parameters

AUC (95% CI)

cutoff value

SEN

SPE

PPV

NPV

LR+

LR-

For all patients

Age (years)

0.674 (0.623, 0.723)

> 66

74.2

52.9

26.5

90

1.58

0.49

α-HBDH (U/L)

0.829 (0.784,0.867)

> 674.49

65.6

88.8

56.3

92.1

5.84

0.39

AST/ALT ratio

0.842 (0.800, 0.879)

> 2.26

87.9

65.1

36.5

95.9

2.51

0.19

mAST/ALT ratio

0.803 (0.757, 0.843)

> 0.659

69.2

80.6

44.6

92.1

3.57

0.38

cAST/ALT ratio

0.847 (0.805, 0.883)

> 1.728

86.2

69.2

38.6

95.7

2.8

0.2

M1

0.888 (0.851, 0.919)

> 10.21

78.8

83.4

52.0

94.5

4.74

0.25

sM1

0.889 (0.852, 0.920)

> 11.36

83.3

79.6

48.2

95.4

4.08

0.21

M2

0.878 (0.840, 0.910 )

> 9.604

83.3

81.3

50.5

95.5

4.46

0.20

sM2

0.877 (0.838, 0.909)

> 10.279

86.4

77.2

46.3

96.1

3.78

0.18

M3

0.880 (0.841, 0.912)

> 9.958

86.4

76.1

45.2

96.1

3.62

0.18

sM3

0.880 (0.842, 0.912)

> 10.562

84.9

76.5

45.2

95.7

3.61

0.20

For ICU patients

AST/ALT ratio

0.731 (0.618, 0.826)

> 3.3

63.6

77.3

67.7

73.9

2.8

0.47

mAST/ALT ratio

0.743 (0.631, 0.836)

> 0.553

90.9

47.7

56.6

87.5

1.74

0.19

cAST/ALT ratio

0.723 (0.609, 0.819)

> 2.50

63.4

77.3

67.7

73.9

2.8

0.47

  1. ICU: intensive care unit; AUC: area under ROC curve; SEN: sensitivity; SPE: specificity; PPV: positive predictive value; NPV: negative predictive value; LR+: positive likelihood ratio; LR-: negative likelihood ratio; M: risk score model; sM: simplified risk model; HBDH:hydroxybutyrate dehydrogenase