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Table 1 Patients characteristics, clinical presentation and microbiology

From: Efficacy of single antibiotic therapy versus antibiotic combination in implant-free staphylococcal post-surgical spinal infections: a retrospective observational study

 

Overall

(N = 20)

Single therapy (N = 11)

Combination therapy (N = 9)

P value

Patients characteristics

   

Men (n, %)

10 (50.0%)

6 (54.5%)

4 (44.4%)

1.00

Age (year), (median [IQR])

60.0 [47.5;69.2]

60.0 [52.0;74.0]

57.0 [46.0;67.0]

0.27

BMI (kg/m2), (median [IQR])

26.0 [23.2;27.7]

26.1 [23.3;29.3]

25.3 [23.0;26.4]

0.69

eGFR (ml/min/1.73m2) (median [IQR])

94.5 [78.5;111]

95.0 [71.5;114]

91.0 [84.0;109]

0.76

Charlson comorbidity index (with age) (median [IQR])

2.00 [0.75;4.25]

4.00 [0.50;6.50]

2.00 [1.00;2.00]

0.17

Primary surgery characteristics

    

Number of previous spinal surgery (median [IQR])

1.00 [1.00;1.00]

1.00 [1.00;1.00]

1.00 [1.00;1.00]

0.67

Surgical indication (n, %)

    

 Degenerative spine disease

19 (95.0%)

10 (90.9%)

9 (100%)

1.00

 Vertebral metastasis

1 (5.00%)

1 (9.09%)

0 (0.00%)

 

Laminectomy (n, %)

20 (100%)

11 (100%)

9 (100%)

 

Spinal implants (n, %)

2 (10.0%)

2 (18.2%)

0 (0.00%)

 

Extent of surgery (number of vertebrae involved) (median [IQR])

3.00 [2.00;4.00]

4.00 [2.50;4.50]

2.00 [2.00;3.00]

0.05

Initial ASA score (median [IQR])

2.00 [1.00;3.00]

2.00 [1.50;3.00]

1.00 [1.00;2.00]

0.20

Post-surgical spinal infection

    

Delay between first surgery and revision surgery (days) (median [IQR])

22.5 [17.8;29.8]

23.0 [19.5;32.0]

22.0 [17.0;24.0]

0.45

Local signs of infection (n, %)

20 (100%)

11 (100%)

9 (100%)

1.00

Fever (n, %)

6 (30.0%)

4 (36.4%)

2 (22.2%)

0.64

Site of involvement (n, %)

   

0.22

 Cervical spine

4 (20%)

3 (27.3%)

1 (11.1%)

 

 Thoracic spine

1 (5%)

1 (9.09%)

0 (0%)

 

 Lumbar spine

14 (70%)

7 (63.6%)

7 (77.8%)

 

 Sacral spine

3 (15%)

0 (0%)

3 (33.3%)

 

Number of vertebrae involved (median [IQR])

2.50 [2.00;4.00]

4.00 [2.00;4.00]

2.00 [2.00;3.00]

0.13

Blood cultures performed (n, %)

4 (20%)

3 (27%)

1 (11%)

0.59

Positive blood culture, (n, %)

0

0

0

 

Positive surgical cultures if surgery performed (n, %)

20 (100%)

11 (100%)

9 (100%)

1.00

Implant removal (n, %)

2 (10.0%)

2 (18.2%)

0 (0.00%)

 

Staphylococcus aureus (n, %)

16 (80.0%)

9 (81.8%)

7 (77.8%)

1.00

 Wild type* (n, %)

4 (25.0%)

3 (33.0%)

1 (14.0%)

 

 methicillin susceptible (n, %)

16 (100%)

9 (100%)

7 (100%)

 

 fluoroquinolone resistant (n, %)

0

0

0

 

 rifampicin resistant (n, %)

0

0

0

 

Coagulase negative staphylococci (%)

4 (20.0%)

2 (18.2%)

2 (22.2%)

1.00

 methicillin susceptible (n, %)

2 (50%)

1 (50%)

1 (50%)

 

 methicillin resistant (n, %)

2 (50%)

1 (50%)

1 (50%)

 

 fluoroquinolone resistant (n, %)

2 (50%)

1 (50%)

1 (50%)

 

 rifampicin resistant (n, %)

0

0

0

 
  1. *Wild-type Staphyloccus aureus were defined as strains susceptible to all antibiotics (penicillin G, cefoxitin, moxalactam, erythromycin, pristinamycin, clindamycin, rifampin, fusidic acid, tetracycline, kanamycin, tobramycin, gentamicin, fosfomycin, levofloxacin, linezolid, vancomycin, teicoplanin, trimethoprim-sulfamethoxazole, fosfomycin, nitrofuran, novobiocin) tested by disc diffusion method on Mueller-Hinton agar.
  2. Abbreviations: eGFR, estimated Glomerular filtration rate; BMI, body mass index; IQR, interquartile range. Continuous variables were given as median (interquartile range, IQR quartile 25-quartile 75) and analyses were made with Fisher’s exact test. Categorical variables were given as numbers and percentages and analyzed with Mann Whitney’s test.
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BMC Infectious Diseases

ISSN: 1471-2334

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