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Table 2 Subgroup and meta-regression analysis

From: Diagnostic performance of metagenomic next-generation sequencing for the detection of pathogens in cerebrospinal fluid in pediatric patients with central nervous system infection: a systematic review and meta-analysis

Parameter

Subgroup

Number of studies

Sensitivity (95% CI)

I2

p1

(meta-regression)

Specificity (95% CI)

I2

p2

(meta-regression)

Continent

    

0.92

  

0.82

 

Asia

6

0.72 (0.62, 0.81)

72.40%

 

0.91 (0.82, 0.98)

88.66%

 
 

Non-Asian

4

0.60 (0.45, 0.76)

71.16%

 

0.89 (0.75, 1.00)

0.00%

 

Study direction

    

0.79

  

0.67

 

Retrospective

6

0.68 (0.55, 0.81)

70.51%

 

0.96 (0.92, 1.00)

54.57%

 
 

Prospective

4

0.75 (0.59, 0.91)

80.85%

 

0.82 (0.73, 0.91)

75.21%

 

Type of study

    

0.44

  

0.51

 

Cohort

7

0.70 (0.57, 0.83)

74.50%

 

0.82 (0.74, 0.91)

75.21%

 
 

Case–control

3

0.77 (0.53, 1.00)

0.00%

 

0.96 (0.92, 1.00)

10.12%

 

Patients were Severely ill or immunocompromised

    

0.17

  

0.18

 

Yes

1

0.91 (0.94, 1.00)

/

 

0.77 (0.26, 1.00)

/

 
 

No

9

0.67 (0.58, 0.75)

68.56%

 

0.89 (0.82, 0.97)

86.15%

 

Sample method

    

0.28

  

0.96

 

Frozen

4

0.67 (0.53, 0.81)

77.03%

 

0.83 (0.68, 0.97)

80.59%

 
 

Fresh

6

0.68 (0.56, 0.80)

65.60%

 

0.92 (0.86, 0.98)

65.66%

 

Pathogen type

    

0.90

  

0.01

 

Mixed

6

0.75 (0.63, 0.87)

70.81%

 

0.83 (0.78, 0.88)

83.80%

 
 

Isolated

4

0.61 (0.45, 0.76)

26.20%

 

0.94 (0.87, 0.98)

0.00%

 

Sequencing platform

    

0.87

  

0.79

 

BGISEQ

3

0.77 (0.64, 0.90)

0.00%

 

0.93 (0.86, 0.97)

0.00%

 
 

Illumina

7

0.64 (0.53, 0.74)

70.69%

 

0.88 (0.74, 0.95)

86.85%

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