Parameter | Subgroup | Number of studies | Sensitivity (95% CI) | I2 | p1 (meta-regression) | Specificity (95% CI) | I2 | p2 (meta-regression) |
---|---|---|---|---|---|---|---|---|
Continent | Â | Â | Â | Â | 0.92 | Â | Â | 0.82 |
 | Asia | 6 | 0.72 (0.62, 0.81) | 72.40% |  | 0.91 (0.82, 0.98) | 88.66% |  |
 | Non-Asian | 4 | 0.60 (0.45, 0.76) | 71.16% |  | 0.89 (0.75, 1.00) | 0.00% |  |
Study direction | Â | Â | Â | Â | 0.79 | Â | Â | 0.67 |
 | Retrospective | 6 | 0.68 (0.55, 0.81) | 70.51% |  | 0.96 (0.92, 1.00) | 54.57% |  |
 | Prospective | 4 | 0.75 (0.59, 0.91) | 80.85% |  | 0.82 (0.73, 0.91) | 75.21% |  |
Type of study | Â | Â | Â | Â | 0.44 | Â | Â | 0.51 |
 | Cohort | 7 | 0.70 (0.57, 0.83) | 74.50% |  | 0.82 (0.74, 0.91) | 75.21% |  |
 | Case–control | 3 | 0.77 (0.53, 1.00) | 0.00% |  | 0.96 (0.92, 1.00) | 10.12% |  |
Patients were Severely ill or immunocompromised | Â | Â | Â | Â | 0.17 | Â | Â | 0.18 |
 | Yes | 1 | 0.91 (0.94, 1.00) | / |  | 0.77 (0.26, 1.00) | / |  |
 | No | 9 | 0.67 (0.58, 0.75) | 68.56% |  | 0.89 (0.82, 0.97) | 86.15% |  |
Sample method | Â | Â | Â | Â | 0.28 | Â | Â | 0.96 |
 | Frozen | 4 | 0.67 (0.53, 0.81) | 77.03% |  | 0.83 (0.68, 0.97) | 80.59% |  |
 | Fresh | 6 | 0.68 (0.56, 0.80) | 65.60% |  | 0.92 (0.86, 0.98) | 65.66% |  |
Pathogen type | Â | Â | Â | Â | 0.90 | Â | Â | 0.01 |
 | Mixed | 6 | 0.75 (0.63, 0.87) | 70.81% |  | 0.83 (0.78, 0.88) | 83.80% |  |
 | Isolated | 4 | 0.61 (0.45, 0.76) | 26.20% |  | 0.94 (0.87, 0.98) | 0.00% |  |
Sequencing platform | Â | Â | Â | Â | 0.87 | Â | Â | 0.79 |
 | BGISEQ | 3 | 0.77 (0.64, 0.90) | 0.00% |  | 0.93 (0.86, 0.97) | 0.00% |  |
 | Illumina | 7 | 0.64 (0.53, 0.74) | 70.69% |  | 0.88 (0.74, 0.95) | 86.85% |  |