Table 1 Basic patient information
NO. | Country | Age | Gender | cardinal symptom | Underlying diseases/Drug use | Therapeutic process | Ultimate treatment | Prognosis | Means of diagnosis |
|---|---|---|---|---|---|---|---|---|---|
P1 | China | 50 | Female | Cough, Bloodshot sputum | Diabetes | Pulmonary cryptococcosis → Fluconazole 6 month (poor response) → right lower lobe resection. Pathology: Cryptococcus + Aspergillus | Voriconazole | Cure | Thoracoscopic lobectomy |
P2 | China | 38 | Male | Physical examination revealed lung shadow | / | Pulmonary cryptococcosis → Voriconazole 5 m (no absorption) to Fluconazole 3 m (no absorption) → Pathology slide consultation: Cryptococcus + Aspergillus | Voriconazole | Cure | TBLB |
P3 | China | 35 | Male | Cough, Phlegm, Fever | Horseshoe kidney | Pulmonary cryptococcosis → Fluconazole 10 m (first reduced and then increased) →pathology: Aspergillus | Voriconazole | Cure | TBLB + CT-guided percutaneous lung biopsy |
P4 | China | 53 | Male | Physical examination revealed a cavity in the right lung | Diabetes | Pulmonary cryptococcosis → Fluconazole 2 m (first reduced lesion, then no change) → Pathology: pulmonary Aspergillus with cryptococcus | Voriconazole | Cure | TBLB |
P5 | China | 32 | Male | Physical examination revealed a shadow of the lower left lung | / | Pulmonary cryptococcosis → Fluconazole (lesion enlargement)→ Pathology: pulmonary Aspergillus with cryptococcus | Voriconazole | Improvement | TBLB |
P6 | America16 | 31 | Male | Chest pain, Dry cough, Night sweats | / | Pulmonary cryptococcosis + Aspergillus disease → amphotericin B (cavity enlargement) → lobectomy → amphotericin B | Amphotericin B + lobectomy | Improvement | Lobectomy |
P7 | China15 | 33 | Female | Chest pain, Fever | Systemic lupus erythematosus (glucocorticoid hormone + azathioprine) | Pulmonary aspergillosis + pulmonary cryptococcosis → amphotericin B + Fluconazole | Amphotericin B + Fluconazole | Improvement | VATS lung biopsy |
P8 | Japan14 | 74 | Male | Dry cough | Tuberculosis | Suspected malignancy of the left inferior void → lobectomy → pathology: pulmonary aspergillosis + pulmonary cryptococcosis | Not mentioned | Not mentioned | Thoracoscopic lobectomy |
P9 | Japan13 | 64 | Male | Two cavities in the lungs with aspergillus pellets | Rheumatoid arthritis (glucocorticoid + cyclophosphamide) | TBLB was used to diagnose Cryptococcus pneumoniae with fungal spherules → Fluconazole →VATS, and PCR confirmed cryptococcus with aspergillus infection | Fluconazole | Not mentioned | VATS lung biopsy |
P10 | China12 | 33 | Male | Haemoptysis | / | Empiric anti-infective + anti-tuberculosis therapy 1 week (no improvement in symptoms) →VATS left lower lobectomy → Pathology: pulmonary Aspergillus + Cryptococcus pulmonary | Amphotericin B + Fluconazole | Cure | Thoracoscopic lobectomy |
P11 | America11 | 69 | Female | Dyspnoea, Fever, Dry cough, Loss of appetite, Fatigue | Post-bone marrow transplantation | Pulmonary cryptococcosis → Flucytosine + amphotericin B liposomes (aggravation of symptoms and CT findings) | Voriconazole | Improvement | Cryptococcal antigen titre 1:640; BALF-GM test was 3.258 |