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Table 1 Overlapping of forwarding causal associations between gut microbial features and antiviral IgG levels

From: Gut microbial features may influence antiviral IgG levels after vaccination against viral respiratory infectious diseases: the evidence from two-sample bidirectional mendelian randomization

Exposure

Outcome

Fixed-effect

IVW

Random-effect IVW

Weighted median

MR-Egger

Heterogeneity

Pleiotropy

P (IVW)

P (MR Egger)

P value

g_Collinsella

anti-IAV IgG

1.079(1.009,1.153)

1.079(0.997,1.167)

1.048(0.954,1.152)

1.082(0.639,1.835)

0.197

0.131

0.99

 

anti-measles virus IgG

1.11(1.005,1.226)

1.11(1.067,1.155)

1.107(0.978,1.253)

0.969(0.521,1.801)

0.993

0.988

0.677

s_Bifidobacterium_longum

anti-IAV IgG

1.063(1.004,1.125)

1.063(1.013,1.116)

1.063(0.987,1.145)

1.015(0.774,1.33)

0.69

0.605

0.741

 

anti-measles virus IgG

1.124(1.032,1.224)

1.124(1.019,1.24)

1.102(0.977,1.244)

1.269(0.781,2.063)

0.211

0.167

0.629

g_Ruminococcaceae_noname

anti-measles virus IgG

1.051(1.005,1.099)

1.051(1.019,1.084)

1.06(1,1.124)

1.081(0.852,1.372)

0.862

0.792

0.82

 

anti-rubella virus IgG

1.069(1.001,1.142)

1.069(0.993,1.152)

1.034(0.944,1.133)

0.895(0.598,1.339)

0.258

0.245

0.412

PWY0-1061

anti-IAV IgG

1.062(1.003,1.125)

1.062(1.005,1.123)

1.073(0.996,1.156)

1.144(0.866,1.511)

0.462

0.381

0.615

 

anti-measles virus IgG

1.103(1.013,1.201)

1.103(1.042,1.167)

1.1(0.984,1.23)

1.208(0.809,1.804)

0.874

0.82

0.666

PWY-6690

anti-IAV IgG

0.956(0.919,0.994)

0.956(0.927,0.986)

0.97(0.923,1.02)

1.085(0.891,1.322)

0.689

0.841

0.268

 

anti-rubella virus IgG

0.909(0.83,0.995)

0.909(0.771,1.071)

0.973(0.838,1.13)

0.5(0.274,0.915)

0.01

0.125

0.142

PWY-841

anti-measles virus IgG

0.912(0.835,0.995)

0.912(0.838,0.992)

0.912(0.811,1.027)

0.633(0.428,0.938)

0.499

0.754

0.095

 

anti-rubella virus IgG

0.808(0.708,0.922)

0.808(0.689,0.948)

0.813(0.674,0.981)

0.651(0.322,1.318)

0.159

0.13

0.554

 

anti-mumps virus IgG

0.919(0.863,0.978)

0.919(0.869,0.972)

0.909(0.836,0.988)

1.034(0.779,1.371)

0.625

0.602

0.424

PYRIDNUCSAL-PWY

anti-measles virus IgG

1.087(1.005,1.176)

1.087(1.02,1.159)

1.114(1.002,1.238)

0.836(0.555,1.259)

0.748

0.831

0.236

 

anti-rubella virus IgG

1.154(1.033,1.29)

1.154(1.048,1.272)

1.155(0.999,1.336)

1.713(0.873,3.36)

0.652

0.703

0.278

PWY-7446

anti-IAV IgG

0.952(0.919,0.986)

0.952(0.908,0.998)

0.937(0.89,0.985)

0.847(0.661,1.086)

0.101

0.108

0.39

 

anti-mumps virus IgG

0.963(0.929,0.998)

0.963(0.939,0.988)

0.974(0.933,1.018)

1.1(0.921,1.313)

0.82

0.966

0.184

P164-PWY

anti-measles virus IgG

1.012(0.953,1.075)

1.012(0.949,1.079)

0.998(0.919,1.083)

0.75(0.59,0.952)

0.341

0.857

0.031

 

anti-mumps virus IgG

1.076(1.031,1.123)

1.076(1.038,1.116)

1.049(0.99,1.111)

1.029(0.867,1.22)

0.716

0.656

0.607

PWY-HEME-BIOSYNTHESIS-II

anti-rubella virus IgG

0.867(0.777,0.968)

0.867(0.767,0.98)

0.831(0.713,0.969)

1.064(0.705,1.607)

0.267

0.275

0.335

 

anti-mumps virus IgG

0.934(0.886,0.985)

0.934(0.882,0.99)

0.946(0.874,1.024)

0.886(0.716,1.096)

0.273

0.225

0.624

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BMC Infectious Diseases

ISSN: 1471-2334

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