Gut microbial features may influence antiviral IgG levels after vaccination against viral respiratory infectious diseases: the evidence from two-sample bidirectional mendelian randomization

Table 2 Overlapping of potential reverse causal associations between antiviral IgG levels and gut microbial features

Exposure	Outcome	Fixed-effect IVW	Random-effect IVW	Weighted median	MR-Egger	Heterogeneity		Pleiotropy
Exposure	Outcome	Fixed-effect IVW	Random-effect IVW	Weighted median	MR-Egger	P(IVW)	P (MR Egger)	P value
anti-IAV IgG	p_Verrucomicrobia	0.727(0.534,0.989)	0.727(0.614,0.861)	0.685(0.472,0.993)	1.332(0.219,8.094)	0.975	0.972	0.523
anti-rubella virus IgG	p_Verrucomicrobia	1.159(1.001,1.343)	1.159(0.993,1.353)	1.215(0.986,1.498)	0.869(0.43,1.754)	0.355	0.326	0.437
anti-IAV IgG	s_Parabacteroides_merdae	1.385(1.028,1.865)	1.385(1.04,1.845)	1.189(0.802,1.763)	1.602(0.354,7.252)	0.505	0.415	0.851
anti-measles virus IgG	s_Parabacteroides_merdae	1.374(1.126,1.677)	1.374(1.059,1.783)	1.271(0.922,1.752)	1.683(0.625,4.535)	0.073	0.053	0.686
anti-IAV IgG	s_Alistipes_finegoldii	1.413(1.071,1.865)	1.413(1.071,1.864)	1.279(0.861,1.9)	0.678(0.169,2.724)	0.443	0.451	0.318
anti-mumps virus IgG	s_Alistipes_finegoldii	1.544(1.07,2.229)	1.544(1.112,2.145)	1.462(0.904,2.365)	2.169(0.215,21.854)	0.524	0.374	0.789
anti-rubella virus IgG	s_Eubacterium_eligens	1.205(1.045,1.389)	1.205(1.086,1.338)	1.167(0.968,1.407)	1.602(0.852,3.012)	0.829	0.837	0.395
anti-mumps virus IgG	s_Eubacterium_eligens	1.523(1.043,2.225)	1.523(0.927,2.504)	1.193(0.684,2.081)	6.097(0.254,146.094)	0.142	0.138	0.45
anti-rubella virus IgG	s_Bacteroides_plebeius	0.757(0.576,0.995)	0.757(0.63,0.911)	0.742(0.526,1.047)	0.401(0.119,1.349)	0.888	0.925	0.327
anti-mumps virus IgG	s_Bacteroides_plebeius	2.111(1.023,4.356)	2.111(0.985,4.525)	2.99(1.087,8.229)	0.063(0.001,5.133)	0.351	0.59	0.211

ISSN: 1471-2334