MIC (µg/mL) | FICA/FICB | FIC index | Interpretation | No. of isolates | P value | |
Alone | In combination | |||||
Ampicillin /Monolaurin | Ampicillin /Monolaurin | |||||
8/1000 | 1/250 | 0.125/0.25 | 0.375 | Synergistic | 15 | < 0.001 |
8/250 | 1/250 | 0.125/1 | 1.125 | Indifference | 3 | |
8/1000 | 2/250 | 0.25/0.25 | 0.5 | Synergistic | 20 | |
16/500 | 1/250 | 0.0625/0.5 | 0.5625 | Partial synergy | 9 | |
16/1000 | 4/250 | 0.25/0.25 | 0.5 | Synergistic | 7 | |
32/1000 | 1/250 | 0.03125/0.25 | 0.281 | Synergistic | 16 | |
32/1000 | 4/250 | 0.125/0.25 | 0.375 | Synergistic | 22 | |
32/2000 | 1/250 | 0.03125/0.125 | 0.1562 | Synergistic | 3 | |
32/2000 | 4/250 | 0.125/0.125 | 0.25 | Synergistic | 8 | |
Amoxicillin (A) /Monolaurin (B) | Amoxicillin (A) /Monolaurin (B) | FIC (A) / FIC (B) | FIC index | Interpretation | No. of isolates | P value |
32/250 | 0.5/250 | 0.015625/1 | 1.015 | Indifference | 3 | < 0.001 |
32/1000 | 0.5/250 | 0.015625/0.25 | 0.265 | Synergistic | 3 | |
32/1000 | 4/250 | 0.125/0.25 | 0.375 | Synergistic | 2 | |
32/500 | 4/250 | 0.125/0.5 | 0.625 | Partial synergy | 9 | |
32/1000 | 8/250 | 0.25/0.25 | 0.5 | Synergistic | 12 | |
64/1000 | 0.5/250 | 0.0078/0.25 | 0.2578 | Synergistic | 32 | |
64/1000 | 2/250 | 0.03125/0.25 | 0.281 | Synergistic | 5 | |
64/1000 | 4/250 | 0.0625/0.25 | 0.3125 | Synergistic | 16 | |
64/1000 | 8/250 | 0.125/0.25 | 0.375 | Synergistic | 11 | |
128/1000 | 1/250 | 0.0078/0.25 | 0.2578 | Synergistic | 2 | |
128/2000 | 1/250 | 0.0078/0.125 | 0.1328 | Synergistic | 4 | |
128/2000 | 8/250 | 0.0625/0.125 | 0.1875 | Synergistic | 4 | |
Piperacillin /Monolaurin | Piperacillin /Monolaurin | FIC (A) / FIC (B) | FIC index | Interpretation | No. of isolates | P value |
16/250 | 4 | 0.25/1 | 1.25 | Indifference | 2 | < 0.001 |
16/250 | 8 | 0.5/1 | 1.5 | Indifference | 1 | |
16/1000 | 8 | 0.5/0.25 | 0.75 | Partial synergy | 17 | |
64/1000 | 16 | 0.25/0.25 | 0.5 | Synergistic | 12 | |
64/500 | 8/250 | 0.0625/0.5 | 0.5625 | Partial synergy | 9 | |
128/1000 | 16 | 0.125/0.25 | 0.375 | Synergistic | 20 | |
128/1000 | 32 | 0.25/0.25 | 0.5 | Synergistic | 16 | |
256/1000 | 32/250 | 0.125/0.25 | 0.375 | Synergistic | 14 | |
256/1000 | 8/250 | 0.03125/0.25 | 0.28125 | Synergistic | 4 | |
256/2000 | 8/250 | 0.03125/0.125 | 0.15625 | Synergistic | 8 |